Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-ca… 158985-25-2

Name: Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate
Brand: Vaqora Chemicals
SKU: VQ-048745

About Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

Vaqora Chemicals supplies Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate, a metabolite or degradation product of Ketoconazole registered under CAS number 158985-25-2. Its molecular formula is C15H22N2O3 and its molecular weight is 278.35 g/mol. It is also known as N-Boc-4-(4-Hydroxyphenyl)piperazine or 1-boc-4-(4-hydroxyphenyl)piperazine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Ketoconazole, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ketoconazole

View every impurity, metabolite and intermediate we list for Ketoconazole.

Ketoconazole impurities

Specifications & identifiers

Chemical identifiers
Product name	Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate
Catalogue No.	VQ-048745
CAS Number	158985-25-2
IUPAC name	tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate
Molecular formula	C₁₅H₂₂N₂O₃
Molecular weight	278.35 g/mol
Exact mass	278.163
Grade	Reference Standard
HSN code	38229090
InChIKey	YEHWSWXESXPBOS-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCN(CC1)C2=CC=C(C=C2)O
PubChem CID	11687740

Physical properties
Physical form	Solid
LogP (XLogP3)	2.3
H-bond donors / acceptors	1 / 4
TPSA	53 Å²
Synonyms	4-(4-Hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester, N-Boc-4-(4-Hydroxyphenyl)piperazine, 1-boc-4-(4-hydroxyphenyl)piperazine, 4-(4-Boc-1-piperazinyl)phenol, 4-(4-Hydroxyphenyl)piperazine-1-carboxylic acid tert-butyl ester, 4-(4-Hydroxyphenyl)piperazine, N1-BOC protected, 4-BOC-1-(4-hydroxyphenyl)piperazine, 4-(4-tert-butoxycarbonylpiperazin-1-yl)phenol, 1-(4-Hydroxyphenyl)-4-tert-butoxycarbonylpiperazine, tert-butyl 4-(4-hydroxyphenyl)piperazinecarboxylate, 1-(tert-butoxycarbonyl)-4-(4-hydroxyphenyl)piperazine, 1-(tert-butyloxycarbonyl)-4-(4-hydroxyphenyl)piperazine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate?

The CAS Registry Number of Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate is 158985-25-2. It is also known as 4-(4-Hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester, N-Boc-4-(4-Hydroxyphenyl)piperazine, 1-boc-4-(4-hydroxyphenyl)piperazine.

What is the molecular formula and molecular weight of Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate?

Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate has the molecular formula C15H22N2O3 and a molecular weight of 278.35 g/mol. Its IUPAC name is tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate.

What is Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate used for?

Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate is supplied as a characterised reference material related to Ketoconazole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate can I order?

We supply Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate?

Yes. Every lot of Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate be shipped internationally?

Yes. Tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.