Tofacitinib N-Nitroso impurity

Name: Tofacitinib N-Nitroso impurity
Brand: Vaqora Chemicals
SKU: VQ-007054

About Tofacitinib N-Nitroso impurity

Tofacitinib N-Nitroso impurity is a nitrosamine impurity of Tofacitinib from the Vaqora Chemicals catalogue with a typical assay of 96.50%. Formula C13H18N6O, molecular weight 274.32 g/mol. The IUPAC name is N-methyl-N-[(3R,4R)-4-methyl-1-nitrosopiperidin-3-yl]-5H-pyrrolo[2,3-d]pyrimidin-4-amine. It is also known as (3R,4R)-1-Nitroso Tofacitinib.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Tofacitinib, method validation (AMV) and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Tofacitinib N-Nitroso impurity in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Tofacitinib

View every impurity, metabolite and intermediate we list for Tofacitinib.

Tofacitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Tofacitinib N-Nitroso impurity
Catalogue No.	VQ-007054
IUPAC name	N-methyl-N-[(3R,4R)-4-methyl-1-nitrosopiperidin-3-yl]-5H-pyrrolo[2,3-d]pyrimidin-4-amine
Molecular formula	C₁₃H₁₈N₆O
Molecular weight	274.32 g/mol
Exact mass	274.1542
Grade	Reference Standard
Purity / assay	96.50%
HSN code	38229090
InChIKey	TXSGUQKMDXUZIR-KOLCDFICSA-N
SMILES	C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2CC=N3)N=O
PubChem CID	169444598

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	0 / 7
TPSA	74.1 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the molecular formula and molecular weight of Tofacitinib N-Nitroso impurity?

Tofacitinib N-Nitroso impurity has the molecular formula C13H18N6O and a molecular weight of 274.32 g/mol. Its IUPAC name is N-methyl-N-[(3R,4R)-4-methyl-1-nitrosopiperidin-3-yl]-5H-pyrrolo[2,3-d]pyrimidin-4-amine.

What is Tofacitinib N-Nitroso impurity used for?

Tofacitinib N-Nitroso impurity is supplied as a characterised reference material related to Tofacitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tofacitinib N-Nitroso impurity can I order?

We supply Tofacitinib N-Nitroso impurity in Reference Standard (96.50%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tofacitinib N-Nitroso impurity?

Yes. Every lot of Tofacitinib N-Nitroso impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tofacitinib N-Nitroso impurity be shipped internationally?

Yes. We export Tofacitinib N-Nitroso impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.