Trimethoprim EP Impurity E

Name: Trimethoprim EP Impurity E
Brand: Vaqora Chemicals
SKU: VQ-034441

About Trimethoprim EP Impurity E

Vaqora Chemicals supplies Trimethoprim EP Impurity E, a pharmacopeial impurity of Trimethoprim registered under CAS number 60729-91-1. The compound has the formula C14H17N3O4, corresponding to a molecular weight of 291.3 g/mol. Systematically, it is named 6-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-2-one. It is also known as Trimethoprim - Impurity E or 2-Desamino-2-hydroxy trimethoprim.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Trimethoprim to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Trimethoprim

View every impurity, metabolite and intermediate we list for Trimethoprim.

Trimethoprim impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Trimethoprim EP Impurity E
Catalogue No.	VQ-034441
CAS Number	60729-91-1
IUPAC name	6-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-2-one
Molecular formula	C₁₄H₁₇N₃O₄
Molecular weight	291.3 g/mol
Exact mass	291.1219
Grade	Reference Standard
HSN code	38229090
InChIKey	OYDLMYVTTNXWRD-UHFFFAOYSA-N
SMILES	COC1=CC(=CC(=C1OC)OC)CC2=C(NC(=O)N=C2)N
PubChem CID	13734022

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	2 / 5
TPSA	95.2 Å²
Synonyms	Trimethoprim - Impurity E, 2-Desamino-2-hydroxy trimethoprim, 4-Amino-5-(3,4,5-trimethoxybenzyl)pyrimidin-2-ol, 2(1H)-Pyrimidinone, 6-amino-5-((3,4,5-trimethoxyphenyl)methyl)-, Trimethoprim Impurity E, 2(1H)-Pyrimidinone, 6-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-, 4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-2(1H)-pyrimidinone, 6-Amino-5-(3,4,5-trimethoxybenzyl)pyrimidin-2(1H)-one, 4-Amino-5-(3,4,5-trimethoxybenzyl)p, 4-Amino-5-(3,4,5-trimethoxybenzyl) pyrimidin-2-ol, 6-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1,2-dihydropyrimidin-2-one, 6-Amino-5-(3,4,5-trimethoxybenzyl)pyrimidin-2(1H)-one, Trimethoprim Impurity

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed

Precautionary statements: P203, P264, P270, P280, P301 + P316, P301 + P317, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trimethoprim EP Impurity E?

The CAS Registry Number of Trimethoprim EP Impurity E is 60729-91-1. It is also known as Trimethoprim - Impurity E, 2-Desamino-2-hydroxy trimethoprim, 4-Amino-5-(3,4,5-trimethoxybenzyl)pyrimidin-2-ol.

What is the molecular formula and molecular weight of Trimethoprim EP Impurity E?

Trimethoprim EP Impurity E has the molecular formula C14H17N3O4 and a molecular weight of 291.3 g/mol. Its IUPAC name is 6-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-2-one.

What is Trimethoprim EP Impurity E used for?

Trimethoprim EP Impurity E is supplied as a characterised reference material related to Trimethoprim. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trimethoprim EP Impurity E can I order?

We supply Trimethoprim EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trimethoprim EP Impurity E?

Yes. Every lot of Trimethoprim EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trimethoprim EP Impurity E be shipped internationally?

Yes. Trimethoprim EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.