Daclatasvir EP Impurity H (Freebase)

Name: Daclatasvir EP Impurity H (Freebase)
Brand: Vaqora Chemicals
SKU: VQ-006314

About Daclatasvir EP Impurity H (Freebase)

Listed under CAS 1007882-27-0, Daclatasvir EP Impurity H (Freebase) is a pharmacopeial impurity of Daclatasvir available from Vaqora Chemicals. Its molecular formula is C26H28N6 and its molecular weight is 424.5 g/mol. Its systematic (IUPAC) name is 2-[(2S)-pyrrolidin-2-yl]-5-[4-[4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazole. It is also known as Daclatasvir Intermediate or Daclatasvir Impurity 50.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Daclatasvir to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Daclatasvir EP Impurity H (Freebase) is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Daclatasvir

View every impurity, metabolite and intermediate we list for Daclatasvir.

Daclatasvir impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Daclatasvir EP Impurity H (Freebase)
Catalogue No.	VQ-006314
CAS Number	1007882-27-0
IUPAC name	2-[(2S)-pyrrolidin-2-yl]-5-[4-[4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazole
Molecular formula	C₂₆H₂₈N₆
Molecular weight	424.5 g/mol
Exact mass	424.2375
Grade	Reference Standard
HSN code	38229090
InChIKey	UXYVOBIJTHABEM-VXKWHMMOSA-N
SMILES	C1C[C@H](NC1)C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6
PubChem CID	24957158

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	4 / 4
TPSA	81.4 Å²
Synonyms	5,5'-[1,1'-Biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole], 5,5-[1,1-Biphenyl]-4,4-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole], Daclatasvir Intermediate, 4,4'-Bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,1'-biphenyl, Daclatasvir Impurity 50

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements: P233, P260, P271, P284, P304 + P340, P342 + P316, P403, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Daclatasvir EP Impurity H (Freebase)?

The CAS Registry Number of Daclatasvir EP Impurity H (Freebase) is 1007882-27-0. It is also known as 5,5'-[1,1'-Biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole], 5,5-[1,1-Biphenyl]-4,4-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole], Daclatasvir Intermediate.

What is the molecular formula and molecular weight of Daclatasvir EP Impurity H (Freebase)?

Daclatasvir EP Impurity H (Freebase) has the molecular formula C26H28N6 and a molecular weight of 424.5 g/mol. Its IUPAC name is 2-[(2S)-pyrrolidin-2-yl]-5-[4-[4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazole.

What is Daclatasvir EP Impurity H (Freebase) used for?

Daclatasvir EP Impurity H (Freebase) is supplied as a characterised reference material related to Daclatasvir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Daclatasvir EP Impurity H (Freebase) can I order?

We supply Daclatasvir EP Impurity H (Freebase) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Daclatasvir EP Impurity H (Freebase)?

Yes. Every lot of Daclatasvir EP Impurity H (Freebase) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Daclatasvir EP Impurity H (Freebase) be shipped internationally?

Yes. Daclatasvir EP Impurity H (Freebase) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.