3-O-Methyl Estradiol

Name: 3-O-Methyl Estradiol
Brand: Vaqora Chemicals
SKU: VQ-025646

About 3-O-Methyl Estradiol

3-O-Methyl Estradiol (CAS 1035-77-4) is an impurity of Estradiol offered by Vaqora Chemicals. Its molecular formula is C19H26O2 and its molecular weight is 286.4 g/mol. The IUPAC name is (8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol. Alternative names: Estradiol 3-methyl ether and 3-Methoxyoestradiol.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

This Estradiol impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 3-O-Methyl Estradiol in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Estradiol

View every impurity, metabolite and intermediate we list for Estradiol.

Estradiol impurities

Specifications & identifiers

Chemical identifiers
Product name	3-O-Methyl Estradiol
Catalogue No.	VQ-025646
CAS Number	1035-77-4
IUPAC name	(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol
Molecular formula	C₁₉H₂₆O₂
Molecular weight	286.4 g/mol
Exact mass	286.1933
Grade	Reference Standard
HSN code	38229090
InChIKey	ULAADVBNYHGIBP-GFEQUFNTSA-N
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC
PubChem CID	246206

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	1 / 2
TPSA	29.5 Å²
Synonyms	Estradiol 3-methyl ether, 3-Methoxyoestradiol, 3-Methoxyestradiol, Estradiol-17beta-3-methyl ether, 3-Methoxyoestra-1,3,5(10)-trien-17-beta-ol, (17-beta)-3-Methoxyestra-1,3,5(10)-trien-17-ol, ESTRA-1,3,5(10)-TRIEN-17-beta-OL, 3-METHOXY-, Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, (17-beta)-, 17beta-Estradiol 3-methyl ether, Oestradiol 3-methyl ether, 17.beta.-Estradiol 3-methyl ether

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements: P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-O-Methyl Estradiol?

The CAS Registry Number of 3-O-Methyl Estradiol is 1035-77-4. It is also known as Estradiol 3-methyl ether, 3-Methoxyoestradiol, 3-Methoxyestradiol.

What is the molecular formula and molecular weight of 3-O-Methyl Estradiol?

3-O-Methyl Estradiol has the molecular formula C19H26O2 and a molecular weight of 286.4 g/mol. Its IUPAC name is (8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol.

What is 3-O-Methyl Estradiol used for?

3-O-Methyl Estradiol is supplied as a characterised reference material related to Estradiol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-O-Methyl Estradiol can I order?

We supply 3-O-Methyl Estradiol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-O-Methyl Estradiol?

Yes. Every lot of 3-O-Methyl Estradiol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-O-Methyl Estradiol be shipped internationally?

Yes. 3-O-Methyl Estradiol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.