4,6-Dimethyl-2-hydroxypyrimidine

About 4,6-Dimethyl-2-hydroxypyrimidine

4,6-Dimethyl-2-hydroxypyrimidine is a metabolite or degradation product of Ambrisentan carrying the CAS registry number 108-79-2. Its molecular formula is C6H8N2O and its molecular weight is 124.14 g/mol. Systematically, it is named 4,6-dimethyl-1H-pyrimidin-2-one. Common synonyms include 2-Hydroxy-4,6-Dimethylpyrimidine and 2-Hydroxy-4,6-dimethyl Pyrimidine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Ambrisentan, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Ambrisentan

View every impurity, metabolite and intermediate we list for Ambrisentan.

Ambrisentan impurities

Specifications & identifiers

Chemical identifiers
Product name	4,6-Dimethyl-2-hydroxypyrimidine
Catalogue No.	VQ-024228
CAS Number	108-79-2
IUPAC name	4,6-dimethyl-1H-pyrimidin-2-one
Molecular formula	C₆H₈N₂O
Molecular weight	124.14 g/mol
Exact mass	124.0637
Grade	Reference Standard
HSN code	38229090
InChIKey	WHEQVHAIRSPYDK-UHFFFAOYSA-N
SMILES	CC1=CC(=NC(=O)N1)C
PubChem CID	9508

Physical properties
Physical form	Solid
H-bond donors / acceptors	1 / 1
TPSA	41.5 Å²
Synonyms	2-Hydroxy-4,6-Dimethylpyrimidine, 2-Hydroxy-4,6-dimethyl Pyrimidine, 4,6-Dimethylpyrimidin-2-ol, 2(1H)-Pyrimidinone, 4,6-dimethyl-, 4,6-dimethylpyrimidin-2(1H)-one, 4,6-Dimethyl-2-pyrimidinol, 4,6-dimethyl-2(1H)-pyrimidinone, 4,6-Dimethyl-2-pyrimidone, 4,6-dimethyl-1,2-dihydro-2-pyrimidone, 4,6-dimethyl-1,2-dihydropyrimidin-2-one, 4,6-Dimethyl-pyrimidin-2-ol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4,6-Dimethyl-2-hydroxypyrimidine?

The CAS Registry Number of 4,6-Dimethyl-2-hydroxypyrimidine is 108-79-2. It is also known as 2-Hydroxy-4,6-Dimethylpyrimidine, 2-Hydroxy-4,6-dimethyl Pyrimidine, 4,6-Dimethylpyrimidin-2-ol.

What is the molecular formula and molecular weight of 4,6-Dimethyl-2-hydroxypyrimidine?

4,6-Dimethyl-2-hydroxypyrimidine has the molecular formula C6H8N2O and a molecular weight of 124.14 g/mol. Its IUPAC name is 4,6-dimethyl-1H-pyrimidin-2-one.

What is 4,6-Dimethyl-2-hydroxypyrimidine used for?

4,6-Dimethyl-2-hydroxypyrimidine is supplied as a characterised reference material related to Ambrisentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4,6-Dimethyl-2-hydroxypyrimidine can I order?

We supply 4,6-Dimethyl-2-hydroxypyrimidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4,6-Dimethyl-2-hydroxypyrimidine?

Yes. Every lot of 4,6-Dimethyl-2-hydroxypyrimidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4,6-Dimethyl-2-hydroxypyrimidine be shipped internationally?

Yes. 4,6-Dimethyl-2-hydroxypyrimidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.