4-Hydroxy-N-Desmethyl Tamoxifen

About 4-Hydroxy-N-Desmethyl Tamoxifen

4-Hydroxy-N-Desmethyl Tamoxifen is a metabolite or degradation product of Tamoxifen carrying the CAS registry number 112093-28-4. With the molecular formula C25H27NO2, it has a molar mass of 373.5 g/mol. Its systematic (IUPAC) name is 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol. Alternative names: Z-Endoxifen and (Z)-4-Hydroxy-N-Desmethyl Tamoxifen.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Tamoxifen, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Tamoxifen

View every impurity, metabolite and intermediate we list for Tamoxifen.

Tamoxifen impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy-N-Desmethyl Tamoxifen
Catalogue No.	VQ-034366
CAS Number	112093-28-4
IUPAC name	4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
Molecular formula	C₂₅H₂₇NO₂
Molecular weight	373.5 g/mol
Exact mass	373.2042
Grade	Reference Standard
HSN code	38229090
InChIKey	MHJBZVSGOZTKRH-IZHYLOQSSA-N
SMILES	CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCNC)/C3=CC=CC=C3
PubChem CID	10090750

Physical properties
Physical form	Solid
LogP (XLogP3)	6.3
H-bond donors / acceptors	2 / 3
TPSA	41.5 Å²
Synonyms	Z-Endoxifen, (Z)-4-Hydroxy-N-Desmethyl Tamoxifen, N-Desmethyl-4-hydroxytamoxifen, 4-[(~{Z})-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol, 4-((~(Z))-1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, 4OHNDtam, (Z)-Endoxifen, Endoxifen Z-Isomer, (E/Z)-Endoxifen, Endoxifen (Z-isomer)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P261, P264, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P317, P318, P321, P330, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy-N-Desmethyl Tamoxifen?

The CAS Registry Number of 4-Hydroxy-N-Desmethyl Tamoxifen is 112093-28-4. It is also known as Z-Endoxifen, (Z)-4-Hydroxy-N-Desmethyl Tamoxifen, N-Desmethyl-4-hydroxytamoxifen.

What is the molecular formula and molecular weight of 4-Hydroxy-N-Desmethyl Tamoxifen?

4-Hydroxy-N-Desmethyl Tamoxifen has the molecular formula C25H27NO2 and a molecular weight of 373.5 g/mol. Its IUPAC name is 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol.

What is 4-Hydroxy-N-Desmethyl Tamoxifen used for?

4-Hydroxy-N-Desmethyl Tamoxifen is supplied as a characterised reference material related to Tamoxifen. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy-N-Desmethyl Tamoxifen can I order?

We supply 4-Hydroxy-N-Desmethyl Tamoxifen in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy-N-Desmethyl Tamoxifen?

Yes. Every lot of 4-Hydroxy-N-Desmethyl Tamoxifen is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy-N-Desmethyl Tamoxifen be shipped internationally?

Yes. 4-Hydroxy-N-Desmethyl Tamoxifen is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.