Olopatadine N-Desmethyl Impurity

About Olopatadine N-Desmethyl Impurity

Olopatadine N-Desmethyl Impurity is a nitrosamine impurity of Olopatadine carrying the CAS registry number 113835-92-0. The compound has the formula C20H21NO3, corresponding to a molecular weight of 323.4 g/mol. Systematically, it is named 2-[(11Z)-11-[3-(methylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid. Common synonyms include N-Desmethyl Olopatadine and Olopatadine (m1).

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Olopatadine N-Desmethyl Impurity is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Olopatadine

View every impurity, metabolite and intermediate we list for Olopatadine.

Olopatadine impurities

Specifications & identifiers

Chemical identifiers
Product name	Olopatadine N-Desmethyl Impurity
Catalogue No.	VQ-007016
CAS Number	113835-92-0
IUPAC name	2-[(11Z)-11-[3-(methylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid
Molecular formula	C₂₀H₂₁NO₃
Molecular weight	323.4 g/mol
Exact mass	323.1521
Grade	Reference Standard
HSN code	38229090
InChIKey	VQMJUHOJPCPUAM-IDUWFGFVSA-N
SMILES	CNCC/C=C\1/C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O
PubChem CID	14127209

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	2 / 4
TPSA	58.6 Å²
Synonyms	N-Nitroso-N-Desmethyl Olopatadine Impurity (n-1), (Z)-2-(11-(3-(methylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid, (11Z)-6,11-Dihydro-11-[3-(methylamino)propylidene]dibenz[b,e]oxepin-2-acetic acid, N-Desmethyl Olopatadine, Olopatadine (m1), Olopatadine metabolite(m1), Dibenz(b,E)oxepin-2-acetic acid, 6,11-dihydro-11-(3-(methylamino)propylidene)-, (11Z)-, N-Monodemethylolopatadine, Olopatadine Impurity 9, N-Desmethyl Olopatadine HCl, (E)-2-[11-[3-(Methylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetic Acid, N-Mono-demethyl-KW-4679 (M1)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Olopatadine N-Desmethyl Impurity?

The CAS Registry Number of Olopatadine N-Desmethyl Impurity is 113835-92-0. It is also known as N-Nitroso-N-Desmethyl Olopatadine Impurity (n-1), (Z)-2-(11-(3-(methylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid, (11Z)-6,11-Dihydro-11-[3-(methylamino)propylidene]dibenz[b,e]oxepin-2-acetic acid.

What is the molecular formula and molecular weight of Olopatadine N-Desmethyl Impurity?

Olopatadine N-Desmethyl Impurity has the molecular formula C20H21NO3 and a molecular weight of 323.4 g/mol. Its IUPAC name is 2-[(11Z)-11-[3-(methylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid.

What is Olopatadine N-Desmethyl Impurity used for?

Olopatadine N-Desmethyl Impurity is supplied as a characterised reference material related to Olopatadine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Olopatadine N-Desmethyl Impurity can I order?

We supply Olopatadine N-Desmethyl Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Olopatadine N-Desmethyl Impurity?

Yes. Every lot of Olopatadine N-Desmethyl Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Olopatadine N-Desmethyl Impurity be shipped internationally?

Yes. We export Olopatadine N-Desmethyl Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.