N-Desmethyl Loperamide-d3

About N-Desmethyl Loperamide-d3

N-Desmethyl Loperamide-d3 is a stable isotope labelled analogue related to Loperamide carrying the CAS registry number 1189488-17-2. Its molecular formula is C28H31ClN2O2 and its molecular weight is 466.0 g/mol. The IUPAC name is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N-(trideuteriomethyl)butanamide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Loperamide and related analytes in bioanalytical, pharmacokinetic and impurity studies. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Desmethyl Loperamide-d3 is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Loperamide

View every impurity, metabolite and intermediate we list for Loperamide.

Loperamide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Loperamide-d3
Catalogue No.	VQ-038114
CAS Number	1189488-17-2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N-(trideuteriomethyl)butanamide
Molecular formula	C₂₈H₃₁ClN₂O₂
Molecular weight	466 g/mol
Exact mass	465.2262
Grade	Reference Standard
HSN code	38229090
InChIKey	ZMOPTLXEYOVARP-FIBGUPNXSA-N
SMILES	[2H]C([2H])([2H])NC(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
PubChem CID	46781171

Physical properties
Physical form	Solid
LogP (XLogP3)	4.8
H-bond donors / acceptors	2 / 3
TPSA	52.6 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Loperamide-d3?

The CAS Registry Number of N-Desmethyl Loperamide-d3 is 1189488-17-2. It is also known as 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-N-(trideuteriomethyl)butanamide, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N-(~2~H_3_)methyl-2,2-diphenylbutanamide.

What is the molecular formula and molecular weight of N-Desmethyl Loperamide-d3?

N-Desmethyl Loperamide-d3 has the molecular formula C28H31ClN2O2 and a molecular weight of 466 g/mol. Its IUPAC name is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N-(trideuteriomethyl)butanamide.

What is N-Desmethyl Loperamide-d3 used for?

N-Desmethyl Loperamide-d3 is supplied as a characterised reference material related to Loperamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Loperamide-d3 can I order?

We supply N-Desmethyl Loperamide-d3 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Loperamide-d3?

Yes. Every lot of N-Desmethyl Loperamide-d3 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Loperamide-d3 be shipped internationally?

Yes. We export N-Desmethyl Loperamide-d3 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.