Leflunomide-d4

About Leflunomide-d4

Leflunomide-d4 is a stable isotope labelled analogue related to Leflunomide carrying the CAS registry number 1189987-23-2. The compound has the formula C12H9F3N2O2, corresponding to a molecular weight of 274.23 g/mol. Its systematic (IUPAC) name is 5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide. It is also known as Leflunomide-d4 (phenyl-d4) or TMID-0237.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Leflunomide and related analytes in bioanalytical, pharmacokinetic and impurity studies. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Leflunomide-d4 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Leflunomide

View every impurity, metabolite and intermediate we list for Leflunomide.

Leflunomide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Leflunomide-d4
Catalogue No.	VQ-031469
CAS Number	1189987-23-2
IUPAC name	5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Molecular formula	C₁₂H₉F₃N₂O₂
Molecular weight	274.23 g/mol
Exact mass	274.0867
Grade	Reference Standard
HSN code	38229090
InChIKey	VHOGYURTWQBHIL-QFFDRWTDSA-N
SMILES	[2H]C1=C(C(=C(C(=C1C(F)(F)F)[2H])[2H])NC(=O)C2=C(ON=C2)C)[2H]
PubChem CID	45039652

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	1 / 6
TPSA	55.1 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Leflunomide-d4?

The CAS Registry Number of Leflunomide-d4 is 1189987-23-2. It is also known as Leflunomide-d4 (phenyl-d4), TMID-0237, 5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide.

What is the molecular formula and molecular weight of Leflunomide-d4?

Leflunomide-d4 has the molecular formula C12H9F3N2O2 and a molecular weight of 274.23 g/mol. Its IUPAC name is 5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide.

What is Leflunomide-d4 used for?

Leflunomide-d4 is supplied as a characterised reference material related to Leflunomide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Leflunomide-d4 can I order?

We supply Leflunomide-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Leflunomide-d4?

Yes. Every lot of Leflunomide-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Leflunomide-d4 be shipped internationally?

Yes. We export Leflunomide-d4 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.