4-Nitro-2-trifluoromethylaniline

About 4-Nitro-2-trifluoromethylaniline

4-Nitro-2-trifluoromethylaniline is a process intermediate or related compound of Enzalutamide carrying the CAS registry number 121-01-7. Its molecular formula is C7H5F3N2O2 and its molecular weight is 206.12 g/mol. Alternative names: 4-Nitro-2-(trifluoromethyl)benzenamine and 1-Amino-2-trifluoromethyl-4-nitrobenzene.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

Process chemists and analysts use it when developing synthetic routes to Enzalutamide, tracking process-related impurities and validating analytical methods. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-Nitro-2-trifluoromethylaniline is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Enzalutamide

View every impurity, metabolite and intermediate we list for Enzalutamide.

Enzalutamide impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Nitro-2-trifluoromethylaniline
Catalogue No.	VQ-013123
CAS Number	121-01-7
IUPAC name	4-nitro-2-(trifluoromethyl)aniline
Molecular formula	C₇H₅F₃N₂O₂
Molecular weight	206.12 g/mol
Exact mass	206.0303
Grade	Reference Standard
HSN code	2933
InChIKey	HOTZLWVITTVZGY-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1[N+](=O)[O-])C(F)(F)F)N
PubChem CID	67128

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	1 / 6
TPSA	71.8 Å²
Synonyms	4-Nitro-2-(trifluoromethyl)benzenamine, 1-Amino-2-trifluoromethyl-4-nitrobenzene, 2-(Trifluoromethyl)-4-nitroaniline, 2-Amino-5-nitrobenzotrifluoride, 4-Nitro-2-trifluoromethylbenzenamine, 4-Nitro-2-trifluoromethylphenylamine, α,α,α-Trifluoro-4-nitro-o-toluidine, 4-Nitro-alpha,alpha,alpha-trifluoro-o-toluidine, Benzenamine, 4-nitro-2-(trifluoromethyl)-, 4-Nitro-a,a,a-trifluoro-o-toluidine, 2-trifluormethyl-4-nitroaniline, 4-Nitro-2-(trifluoromethyl)aniline #

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Nitro-2-trifluoromethylaniline?

The CAS Registry Number of 4-Nitro-2-trifluoromethylaniline is 121-01-7. It is also known as 4-Nitro-2-(trifluoromethyl)benzenamine, 1-Amino-2-trifluoromethyl-4-nitrobenzene, 2-(Trifluoromethyl)-4-nitroaniline.

What is the molecular formula and molecular weight of 4-Nitro-2-trifluoromethylaniline?

4-Nitro-2-trifluoromethylaniline has the molecular formula C7H5F3N2O2 and a molecular weight of 206.12 g/mol. Its IUPAC name is 4-nitro-2-(trifluoromethyl)aniline.

What is 4-Nitro-2-trifluoromethylaniline used for?

4-Nitro-2-trifluoromethylaniline is supplied as a characterised reference material related to Enzalutamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Nitro-2-trifluoromethylaniline can I order?

We supply 4-Nitro-2-trifluoromethylaniline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Nitro-2-trifluoromethylaniline?

Yes. Every lot of 4-Nitro-2-trifluoromethylaniline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Nitro-2-trifluoromethylaniline be shipped internationally?

Yes. 4-Nitro-2-trifluoromethylaniline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.