Larotrectinib WS

Name: Larotrectinib WS
Brand: Vaqora Chemicals
SKU: VQ-007527

About Larotrectinib WS

Listed under CAS 1223403-58-4, Larotrectinib WS is a high-purity reference standard of Larotrectinib available from Vaqora Chemicals. Formula C21H22F2N6O2, molecular weight 428.4 g/mol. Common synonyms include Larotrectinib and ARRY 470.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

As a reference sample of Larotrectinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Larotrectinib WS in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Larotrectinib

View every impurity, metabolite and intermediate we list for Larotrectinib.

Larotrectinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Larotrectinib WS
Catalogue No.	VQ-007527
CAS Number	1223403-58-4
IUPAC name	(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
Molecular formula	C₂₁H₂₂F₂N₆O₂
Molecular weight	428.4 g/mol
Exact mass	428.1772
Grade	Reference Standard
HSN code	38229090
InChIKey	NYNZQNWKBKUAII-KBXCAEBGSA-N
SMILES	C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F
PubChem CID	46188928

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	2 / 7
TPSA	86 Å²
Synonyms	larotrectinib, ARRY 470, LOXO 101, LOXO-101, ARRY-470, Larotrectinib (LOXO-101 free base), Larotrectinib (Standard), Larotrectinib (USAN/INN), ARR Y 470, EX-A1981, example 14 [US8865698 B2]

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Larotrectinib WS?

The CAS Registry Number of Larotrectinib WS is 1223403-58-4. It is also known as larotrectinib, ARRY 470, LOXO 101.

What is the molecular formula and molecular weight of Larotrectinib WS?

Larotrectinib WS has the molecular formula C21H22F2N6O2 and a molecular weight of 428.4 g/mol. Its IUPAC name is (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide.

What is Larotrectinib WS used for?

Larotrectinib WS is supplied as a characterised reference material related to Larotrectinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Larotrectinib WS can I order?

We supply Larotrectinib WS in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Larotrectinib WS?

Yes. Every lot of Larotrectinib WS is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Larotrectinib WS be shipped internationally?

Yes. We export Larotrectinib WS worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.