Abemaciclib

About Abemaciclib

Abemaciclib is a high-purity reference standard of Abemaciclib carrying the CAS registry number 1231929-97-7. The compound has the formula C27H32F2N8, corresponding to a molecular weight of 506.6 g/mol. Alternative names: Verzenio and Verzenios.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Abemaciclib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Abemaciclib is dispatched with a Certificate of Analysis (COA) to destinations worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Abemaciclib

View every impurity, metabolite and intermediate we list for Abemaciclib.

Abemaciclib impurities

Specifications & identifiers

Chemical identifiers
Product name	Abemaciclib
Catalogue No.	VQ-007283
CAS Number	1231929-97-7
IUPAC name	N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
Molecular formula	C₂₇H₃₂F₂N₈
Molecular weight	506.6 g/mol
Exact mass	506.2718
Grade	Reference Standard
HSN code	38229090
InChIKey	UZWDCWONPYILKI-UHFFFAOYSA-N
SMILES	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F
PubChem CID	46220502

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	1 / 9
TPSA	75 Å²
Synonyms	Verzenio, Verzenios, LY2835219 free base, Abemaciclib (ly2835219), Abemaciclib,LY2835219, rimidin-2-amine, Verzenio (TN), 6ZV, Abemaciclib (Standard), CDK4/6 dual inhibitor, Abemaciclib (JAN/USAN/INN), EX-A521

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Abemaciclib?

The CAS Registry Number of Abemaciclib is 1231929-97-7. It is also known as Verzenio, Verzenios, LY2835219 free base.

What is the molecular formula and molecular weight of Abemaciclib?

Abemaciclib has the molecular formula C27H32F2N8 and a molecular weight of 506.6 g/mol. Its IUPAC name is N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine.

What is Abemaciclib used for?

Abemaciclib is supplied as a characterised reference material related to Abemaciclib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Abemaciclib can I order?

We supply Abemaciclib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Abemaciclib?

Yes. Every lot of Abemaciclib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Abemaciclib be shipped internationally?

Yes. Abemaciclib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.