VNL3

About VNL3

VNL3 is a process intermediate or related compound of Venetoclax carrying the CAS registry number 1235865-75-4. Its molecular formula is C15H11FN2O3 and its molecular weight is 286.26 g/mol. Its systematic (IUPAC) name is methyl 4-fluoro-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate. Alternative names: 2-((1H-[2,3-B]-5-))-4-.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to Venetoclax, tracking process-related impurities and validating analytical methods. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer VNL3 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Venetoclax

View every impurity, metabolite and intermediate we list for Venetoclax.

Venetoclax impurities

Specifications & identifiers

Chemical identifiers
Product name	VNL3
Catalogue No.	VQ-013857
CAS Number	1235865-75-4
IUPAC name	methyl 4-fluoro-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate
Molecular formula	C₁₅H₁₁FN₂O₃
Molecular weight	286.26 g/mol
Exact mass	286.0754
Grade	Reference Standard
HSN code	2933
InChIKey	WOXIJNIAUMZYEL-UHFFFAOYSA-N
SMILES	COC(=O)C1=C(C=C(C=C1)F)OC2=CN=C3C(=C2)C=CN3
PubChem CID	66713127

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	1 / 5
TPSA	64.2 Å²
Synonyms	Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-fluorobenzoate, Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate, methyl 4-fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate, Benzoic acid, 4-fluoro-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-, methyl ester, Methyl 2-((1H-pyrrolo(2,3-b)pyridin-5-yl)oxy)-4-fluorobenzoate, Benzoic acid, 4-fluoro-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)-, methyl ester, Methyl 4-fluoro-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzoate, methyl 2-(1h-pyrrolo[2,3-b]pyridin-5-yloxy)-4-fluorobenzoate, 2-((1H-[2,3-B]-5-))-4-, Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-fluoroben, Methyl 2-((1H-pyrrolo[2,3-blpyridin-5-yl)oxy)-4-fluorobenzoate, Methyl2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of VNL3?

The CAS Registry Number of VNL3 is 1235865-75-4. It is also known as Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-fluorobenzoate, Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate, methyl 4-fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate.

What is the molecular formula and molecular weight of VNL3?

VNL3 has the molecular formula C15H11FN2O3 and a molecular weight of 286.26 g/mol. Its IUPAC name is methyl 4-fluoro-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate.

What is VNL3 used for?

VNL3 is supplied as a characterised reference material related to Venetoclax. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of VNL3 can I order?

We supply VNL3 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with VNL3?

Yes. Every lot of VNL3 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can VNL3 be shipped internationally?

Yes. VNL3 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.