6,7-Dimethoxyquinolin-4(1H)-one

Name: 6,7-Dimethoxyquinolin-4(1H)-one
Brand: Vaqora Chemicals
SKU: VQ-040107

About 6,7-Dimethoxyquinolin-4(1H)-one

6,7-Dimethoxyquinolin-4(1H)-one (CAS 127285-54-5) is a process intermediate or related compound of Tivozanib offered by Vaqora Chemicals. Formula C11H11NO3, molecular weight 205.21 g/mol. The IUPAC name is 6,7-dimethoxy-1H-quinolin-4-one. Common synonyms include 6,7-Dimethoxy-4-hydroxyquinoline and 4(1H)-Quinolinone, 6,7-dimethoxy-.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is a process intermediate or related compound in the synthesis of Tivozanib, useful for route development, impurity fate-and-purge studies and analytical method development. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 6,7-Dimethoxyquinolin-4(1H)-one in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Tivozanib

View every impurity, metabolite and intermediate we list for Tivozanib.

Tivozanib impurities

Specifications & identifiers

Chemical identifiers
Product name	6,7-Dimethoxyquinolin-4(1H)-one
Catalogue No.	VQ-040107
CAS Number	127285-54-5
IUPAC name	6,7-dimethoxy-1H-quinolin-4-one
Molecular formula	C₁₁H₁₁NO₃
Molecular weight	205.21 g/mol
Exact mass	205.0739
HSN code	2933
InChIKey	QOGPNCUTXVZQSL-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)C(=O)C=CN2)OC
PubChem CID	459611

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	1 / 4
TPSA	47.6 Å²
Synonyms	6,7-Dimethoxy-4-hydroxyquinoline, 4(1H)-Quinolinone, 6,7-dimethoxy-, 4-Quinolinol, 6,7-dimethoxy-, 6,7-dimethoxy-4(1H)-quinolinone, 6,7-dimethoxyquinolin-4-ol, 4-Hydroxy-6,7-dimethoxyqunioline, 6,7-Dimethoxy-4-quinolinol, 6,7-dimethoxy-1,4-dihydroquinolin-4-one, 6,7-Dimethoxy-1,4-dihydro-4-quinolinone, 6,7-Dimethoxy-quinolin-4-ol, 6,7-Dimethoxy-4-quinolinone

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6,7-Dimethoxyquinolin-4(1H)-one?

The CAS Registry Number of 6,7-Dimethoxyquinolin-4(1H)-one is 127285-54-5. It is also known as 6,7-Dimethoxy-4-hydroxyquinoline, 4(1H)-Quinolinone, 6,7-dimethoxy-, 4-Quinolinol, 6,7-dimethoxy-.

What is the molecular formula and molecular weight of 6,7-Dimethoxyquinolin-4(1H)-one?

6,7-Dimethoxyquinolin-4(1H)-one has the molecular formula C11H11NO3 and a molecular weight of 205.21 g/mol. Its IUPAC name is 6,7-dimethoxy-1H-quinolin-4-one.

What is 6,7-Dimethoxyquinolin-4(1H)-one used for?

6,7-Dimethoxyquinolin-4(1H)-one is supplied as a characterised reference material related to Tivozanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6,7-Dimethoxyquinolin-4(1H)-one can I order?

We supply 6,7-Dimethoxyquinolin-4(1H)-one, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6,7-Dimethoxyquinolin-4(1H)-one?

Yes. Every lot of 6,7-Dimethoxyquinolin-4(1H)-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6,7-Dimethoxyquinolin-4(1H)-one be shipped internationally?

Yes. 6,7-Dimethoxyquinolin-4(1H)-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.