(3S)-4-Chloro-3-hydroxybutyronitrile

About (3S)-4-Chloro-3-hydroxybutyronitrile

(3S)-4-Chloro-3-hydroxybutyronitrile is a metabolite or degradation product of Rosuvastatin carrying the CAS registry number 127913-44-4. With the molecular formula C4H6ClNO, it has a molar mass of 119.55 g/mol. Its systematic (IUPAC) name is (3S)-4-chloro-3-hydroxybutanenitrile. Common synonyms include (S)-4-Chloro-3-hydroxybutyronitrile and (S)-4-chloro-3-hydroxybutanenitrile.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Analytical teams use this compound to identify metabolites and degradants of Rosuvastatin, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Rosuvastatin

View every impurity, metabolite and intermediate we list for Rosuvastatin.

Rosuvastatin impurities

Specifications & identifiers

Chemical identifiers
Product name	(3S)-4-Chloro-3-hydroxybutyronitrile
Catalogue No.	VQ-023412
CAS Number	127913-44-4
IUPAC name	(3S)-4-chloro-3-hydroxybutanenitrile
Molecular formula	C₄H₆ClNO
Molecular weight	119.55 g/mol
Exact mass	119.0138
Grade	Reference Standard
HSN code	38229090
InChIKey	LHBPNZDUNCZWFL-BYPYZUCNSA-N
SMILES	C(C#N)[C@@H](CCl)O
PubChem CID	7020425

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.1
H-bond donors / acceptors	1 / 2
TPSA	44 Å²
Synonyms	(S)-4-Chloro-3-hydroxybutyronitrile, (S)-4-chloro-3-hydroxybutanenitrile, Butanenitrile, 4-chloro-3-hydroxy-, (3S)-, (S)-(-)-4-Chloro-3-hydroxybutyronitrile, (3S)-4-chloro-3-hydroxy-butanenitrile

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (3S)-4-Chloro-3-hydroxybutyronitrile?

The CAS Registry Number of (3S)-4-Chloro-3-hydroxybutyronitrile is 127913-44-4. It is also known as (S)-4-Chloro-3-hydroxybutyronitrile, (S)-4-chloro-3-hydroxybutanenitrile, Butanenitrile, 4-chloro-3-hydroxy-, (3S)-.

What is the molecular formula and molecular weight of (3S)-4-Chloro-3-hydroxybutyronitrile?

(3S)-4-Chloro-3-hydroxybutyronitrile has the molecular formula C4H6ClNO and a molecular weight of 119.55 g/mol. Its IUPAC name is (3S)-4-chloro-3-hydroxybutanenitrile.

What is (3S)-4-Chloro-3-hydroxybutyronitrile used for?

(3S)-4-Chloro-3-hydroxybutyronitrile is supplied as a characterised reference material related to Rosuvastatin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (3S)-4-Chloro-3-hydroxybutyronitrile can I order?

We supply (3S)-4-Chloro-3-hydroxybutyronitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (3S)-4-Chloro-3-hydroxybutyronitrile?

Yes. Every lot of (3S)-4-Chloro-3-hydroxybutyronitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (3S)-4-Chloro-3-hydroxybutyronitrile be shipped internationally?

Yes. (3S)-4-Chloro-3-hydroxybutyronitrile is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.