Famotidine EP impurity E

About Famotidine EP impurity E

Famotidine EP impurity E is a pharmacopeial impurity of Famotidine carrying the CAS registry number 129083-44-9. Formula C10H14N8S4, molecular weight 374.5 g/mol. Systematically, it is named 2-[4-[[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methyldisulfanyl]methyl]-1,3-thiazol-2-yl]guanidine. Common synonyms include Famotidine - Impurity E and Famotidine disulfide.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This Famotidine impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Famotidine EP impurity E in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Famotidine

View every impurity, metabolite and intermediate we list for Famotidine.

Famotidine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Famotidine EP impurity E
Catalogue No.	VQ-025714
CAS Number	129083-44-9
IUPAC name	2-[4-[[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methyldisulfanyl]methyl]-1,3-thiazol-2-yl]guanidine
Molecular formula	C₁₀H₁₄N₈S₄
Molecular weight	374.5 g/mol
Exact mass	374.0224
Grade	Reference Standard
HSN code	38229090
InChIKey	ZWHJVLVEEDAPHN-UHFFFAOYSA-N
SMILES	C1=C(N=C(S1)N=C(N)N)CSSCC2=CSC(=N2)N=C(N)N
PubChem CID	71314076

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.3
H-bond donors / acceptors	4 / 8
TPSA	262 Å²
Synonyms	Famotidine - Impurity E, Famotidine disulfide, Famotidine Impurity E, 2,2'-(Disulfanediylbis(methylenethiazole-4,2-diyl))diguanidine, Guanidine, N,N'''-(dithiobis(methylene-4,2-thiazolediyl))bis-, Bis[(2-guanidino-4-thiazolyl)methyl]disulfide, 2,2'-[Disulfanediylbis-(methylenethiazole-4,2-diyl)]diguanidine, Bis[( (2-guanidino)-4-thiazolyl)methyl]disulfide, N,N''-[dithiobis(methylene-4,2-thiazolediyl)]bis-guanidine, Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide, bis-[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]disulphide, 2,2'-((disulfanediylbis(methylene))bis(thiazole-4,2-diyl))diguanidine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Famotidine EP impurity E?

The CAS Registry Number of Famotidine EP impurity E is 129083-44-9. It is also known as Famotidine - Impurity E, Famotidine disulfide, Famotidine Impurity E.

What is the molecular formula and molecular weight of Famotidine EP impurity E?

Famotidine EP impurity E has the molecular formula C10H14N8S4 and a molecular weight of 374.5 g/mol. Its IUPAC name is 2-[4-[[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methyldisulfanyl]methyl]-1,3-thiazol-2-yl]guanidine.

What is Famotidine EP impurity E used for?

Famotidine EP impurity E is supplied as a characterised reference material related to Famotidine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Famotidine EP impurity E can I order?

We supply Famotidine EP impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Famotidine EP impurity E?

Yes. Every lot of Famotidine EP impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Famotidine EP impurity E be shipped internationally?

Yes. Famotidine EP impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.