(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquin… 1350643-72-9

Name: (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
Brand: Vaqora Chemicals
SKU: VQ-045408

About (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Vaqora Chemicals supplies (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one, an impurity of Duvelisib registered under CAS number 1350643-72-9. Its molecular formula is C17H15ClN2O and its molecular weight is 298.8 g/mol. Its systematic (IUPAC) name is 3-[(1S)-1-aminoethyl]-8-chloro-2-phenylisoquinolin-1-one. Common synonyms include Duvelisib int and CS-M3443.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Duvelisib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Duvelisib

View every impurity, metabolite and intermediate we list for Duvelisib.

Duvelisib impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
Catalogue No.	VQ-045408
CAS Number	1350643-72-9
IUPAC name	3-[(1S)-1-aminoethyl]-8-chloro-2-phenylisoquinolin-1-one
Molecular formula	C₁₇H₁₅ClN₂O
Molecular weight	298.8 g/mol
Exact mass	298.0873
Grade	Reference Standard
HSN code	38229090
InChIKey	MZINZXIFJMLTOK-NSHDSACASA-N
SMILES	C[C@@H](C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)N
PubChem CID	66607319

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	1 / 2
TPSA	46.3 Å²
Synonyms	Duvelisib int, 3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-1,2-dihydroisoquinolin-1-one, CS-M3443, 3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-isoquinolin-1-one, 1(2H)-Isoquinolinone, 3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H312Harmful in contact with skin
H319Causes serious eye irritation

Precautionary statements: P264 + P265, P280, P302 + P352, P305 + P351 + P338, P317, P321, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one?

The CAS Registry Number of (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one is 1350643-72-9. It is also known as Duvelisib int, 3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-1,2-dihydroisoquinolin-1-one, CS-M3443.

What is the molecular formula and molecular weight of (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one?

(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one has the molecular formula C17H15ClN2O and a molecular weight of 298.8 g/mol. Its IUPAC name is 3-[(1S)-1-aminoethyl]-8-chloro-2-phenylisoquinolin-1-one.

What is (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one used for?

(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one is supplied as a characterised reference material related to Duvelisib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one can I order?

We supply (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one?

Yes. Every lot of (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one be shipped internationally?

Yes. (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.