Pemetrexed

Name: Pemetrexed
Brand: Vaqora Chemicals
SKU: VQ-007646

About Pemetrexed

Listed under CAS 137281-23-3, Pemetrexed is a high-purity reference standard of Pemetrexed available from Vaqora Chemicals. With the molecular formula C20H21N5O6, it has a molar mass of 427.4 g/mol. Its systematic (IUPAC) name is (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid. Alternative names: Pemetrexed Sodium and Multitargeted Antifolate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Pemetrexed standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Pemetrexed in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Pemetrexed

View every impurity, metabolite and intermediate we list for Pemetrexed.

Pemetrexed impurities

Specifications & identifiers

Chemical identifiers
Product name	Pemetrexed
Catalogue No.	VQ-007646
CAS Number	137281-23-3
IUPAC name	(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₁N₅O₆
Molecular weight	427.4 g/mol
Exact mass	427.1492
Grade	Reference Standard
HSN code	38229090
InChIKey	WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
SMILES	C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	135410875

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	6 / 7
TPSA	187 Å²
Synonyms	Pemetrexed Sodium, Multitargeted Antifolate, Pemetrexed (INN), 1juj, Pemetrexed Hydrate, Pemetrexed (TN), Pemfexy (TN), Pemetrexed (Standard), Alimta (TN) (Lilly), US9422297, Pemetrexed, Pemetrexed - Bio-X trade mark, Premetrexed [Common mis-spelling]

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pemetrexed?

The CAS Registry Number of Pemetrexed is 137281-23-3. It is also known as Pemetrexed Sodium, Multitargeted Antifolate, Pemetrexed (INN).

What is the molecular formula and molecular weight of Pemetrexed?

Pemetrexed has the molecular formula C20H21N5O6 and a molecular weight of 427.4 g/mol. Its IUPAC name is (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid.

What is Pemetrexed used for?

Pemetrexed is supplied as a characterised reference material related to Pemetrexed. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pemetrexed can I order?

We supply Pemetrexed in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pemetrexed?

Yes. Every lot of Pemetrexed is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pemetrexed be shipped internationally?

Yes. Pemetrexed is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.