Roflumilast Impurity B

Name: Roflumilast Impurity B
Brand: Vaqora Chemicals
SKU: VQ-033632

About Roflumilast Impurity B

Roflumilast Impurity B (CAS 1391052-76-8) is an impurity of Roflumilast offered by Vaqora Chemicals. The compound has the formula C13H8Cl2F2N2O3, corresponding to a molecular weight of 349.11 g/mol. The IUPAC name is N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide. It is also known as 3-O-Decyclopropyl Roflumilast or Roflumilast Descyclopropylmethyl Impurity.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Roflumilast to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Roflumilast Impurity B is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Roflumilast

View every impurity, metabolite and intermediate we list for Roflumilast.

Roflumilast impurities

Specifications & identifiers

Chemical identifiers
Product name	Roflumilast Impurity B
Catalogue No.	VQ-033632
CAS Number	1391052-76-8
IUPAC name	N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide
Molecular formula	C₁₃H₈Cl₂F₂N₂O₃
Molecular weight	349.11 g/mol
Exact mass	347.988
Grade	Reference Standard
HSN code	38229090
InChIKey	GZHTYXYJBZYTEV-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1C(=O)NC2=C(C=NC=C2Cl)Cl)O)OC(F)F
PubChem CID	66777253

Physical properties
Physical form	Solid
LogP (XLogP3)	3.5
H-bond donors / acceptors	2 / 6
TPSA	71.5 Å²
Synonyms	3-O-Decyclopropyl Roflumilast, Roflumilast Descyclopropylmethyl Impurity, Roflumilast Related Compound B, Roflumilast metabolite M05, Roflumilast Impurity E, N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-hydroxybenzamide, Roflumilast Impurity Ii, 3-(Hydroxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide, N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Roflumilast Impurity B?

The CAS Registry Number of Roflumilast Impurity B is 1391052-76-8. It is also known as 3-O-Decyclopropyl Roflumilast, Roflumilast Descyclopropylmethyl Impurity, Roflumilast Related Compound B.

What is the molecular formula and molecular weight of Roflumilast Impurity B?

Roflumilast Impurity B has the molecular formula C13H8Cl2F2N2O3 and a molecular weight of 349.11 g/mol. Its IUPAC name is N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide.

What is Roflumilast Impurity B used for?

Roflumilast Impurity B is supplied as a characterised reference material related to Roflumilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Roflumilast Impurity B can I order?

We supply Roflumilast Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Roflumilast Impurity B?

Yes. Every lot of Roflumilast Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Roflumilast Impurity B be shipped internationally?

Yes. Roflumilast Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.