Lorlatinib

Name: Lorlatinib
Brand: Vaqora Chemicals
SKU: VQ-026507

About Lorlatinib

Vaqora Chemicals supplies Lorlatinib, a high-purity reference standard of Lorlatinib registered under CAS number 1454846-35-5. With the molecular formula C21H19FN6O2, it has a molar mass of 406.4 g/mol. Common synonyms include PF06463922(Lorlatinib) and 4cli.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Lorlatinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Lorlatinib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Lorlatinib

View every impurity, metabolite and intermediate we list for Lorlatinib.

Lorlatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Lorlatinib
Catalogue No.	VQ-026507
CAS Number	1454846-35-5
IUPAC name	(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
Molecular formula	C₂₁H₁₉FN₆O₂
Molecular weight	406.4 g/mol
Exact mass	406.1554
Grade	Reference Standard
HSN code	38229090
InChIKey	IIXWYSCJSQVBQM-LLVKDONJSA-N
SMILES	C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
PubChem CID	71731823

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	1 / 7
TPSA	110 Å²

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Lorlatinib?

The CAS Registry Number of Lorlatinib is 1454846-35-5. It is also known as PF06463922(Lorlatinib), 4cli, 4clj.

What is the molecular formula and molecular weight of Lorlatinib?

Lorlatinib has the molecular formula C21H19FN6O2 and a molecular weight of 406.4 g/mol. Its IUPAC name is (16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile.

What is Lorlatinib used for?

Lorlatinib is supplied as a characterised reference material related to Lorlatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Lorlatinib can I order?

We supply Lorlatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Lorlatinib?

Yes. Every lot of Lorlatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Lorlatinib be shipped internationally?

Yes. Lorlatinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.