Macitentan

Name: Macitentan
Brand: Vaqora Chemicals
SKU: VQ-026547

About Macitentan

Macitentan (CAS 441798-33-0) is a high-purity reference standard of Macitentan offered by Vaqora Chemicals. Its molecular formula is C19H20Br2N6O4S and its molecular weight is 588.3 g/mol. The IUPAC name is 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine. Common synonyms include Actelion-1 and Macitentan (JAN/USAN).

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Macitentan, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Macitentan in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	Macitentan
Catalogue No.	VQ-026547
CAS Number	441798-33-0
IUPAC name	5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
Molecular formula	C₁₉H₂₀Br₂N₆O₄S
Molecular weight	588.3 g/mol
Exact mass	587.9613
Grade	Reference Standard
HSN code	38229090
InChIKey	JGCMEBMXRHSZKX-UHFFFAOYSA-N
SMILES	CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
PubChem CID	16004692

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	2 / 10
TPSA	137 Å²
Synonyms	Actelion-1, Macitentan (JAN/USAN), Macitentan - Bio-X trade mark, EX-A544, Opsynvi (combination of macitentan + tadalafil)

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Macitentan?

The CAS Registry Number of Macitentan is 441798-33-0. It is also known as Actelion-1, Macitentan (JAN/USAN), Macitentan - Bio-X trade mark.

What is the molecular formula and molecular weight of Macitentan?

Macitentan has the molecular formula C19H20Br2N6O4S and a molecular weight of 588.3 g/mol. Its IUPAC name is 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine.

What is Macitentan used for?

Macitentan is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Macitentan can I order?

We supply Macitentan in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Macitentan?

Yes. Every lot of Macitentan is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Macitentan be shipped internationally?

Yes. Macitentan is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.