4,6-Dichloro-2-propylthiopyrimidine-5-amine 145783-15-9

About 4,6-Dichloro-2-propylthiopyrimidine-5-amine

4,6-Dichloro-2-propylthiopyrimidine-5-amine is a process intermediate or related compound of Ticagrelor carrying the CAS registry number 145783-15-9. Formula C7H9Cl2N3S, molecular weight 238.14 g/mol. Its systematic (IUPAC) name is 4,6-dichloro-2-propylsulfanylpyrimidin-5-amine. Alternative names: 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine and 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Ticagrelor, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Ticagrelor

View every impurity, metabolite and intermediate we list for Ticagrelor.

Ticagrelor impurities

Specifications & identifiers

Chemical identifiers
Product name	4,6-Dichloro-2-propylthiopyrimidine-5-amine
Catalogue No.	VQ-013047
CAS Number	145783-15-9
Other CAS	2497548-30-6
IUPAC name	4,6-dichloro-2-propylsulfanylpyrimidin-5-amine
Molecular formula	C₇H₉Cl₂N₃S
Molecular weight	238.14 g/mol
Exact mass	236.9894
Grade	Reference Standard
HSN code	2933
InChIKey	CJJLJBFJNXMANZ-UHFFFAOYSA-N
SMILES	CCCSC1=NC(=C(C(=N1)Cl)N)Cl
PubChem CID	11436336

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	1 / 4
TPSA	77.1 Å²
Synonyms	4,6-Dichloro-2-propylthiopyrimidine-5-amine, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine, 4,6-Dichloro-2-(propylthio)-5-pyrimidinamine, 4,6-Dichloro-2-(propylsulfanyl)-5-pyrimidinamine, 4,6-Dichloro-2-(propylthio) pyrimidine-5-amine, 4,6-Dichloro-2-propylt, CS-M1848, 5-amino-4,6-dichloro-2-propylthiopyrimidine, 4,6-Dichloro-2-propylthio-pyrimidine-5-amine, 4,6-Dichloro-2-propylthiopyrimidine-5-amine, AldrichCPR

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P264, P264 + P265, P270, P273, P280, P301 + P317, P302 + P352, P305 + P351 + P338, P321, P330, P332 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4,6-Dichloro-2-propylthiopyrimidine-5-amine?

The CAS Registry Number of 4,6-Dichloro-2-propylthiopyrimidine-5-amine is 145783-15-9. It is also known as 4,6-Dichloro-2-propylthiopyrimidine-5-amine, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine.

What is the molecular formula and molecular weight of 4,6-Dichloro-2-propylthiopyrimidine-5-amine?

4,6-Dichloro-2-propylthiopyrimidine-5-amine has the molecular formula C7H9Cl2N3S and a molecular weight of 238.14 g/mol. Its IUPAC name is 4,6-dichloro-2-propylsulfanylpyrimidin-5-amine.

What is 4,6-Dichloro-2-propylthiopyrimidine-5-amine used for?

4,6-Dichloro-2-propylthiopyrimidine-5-amine is supplied as a characterised reference material related to Ticagrelor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4,6-Dichloro-2-propylthiopyrimidine-5-amine can I order?

We supply 4,6-Dichloro-2-propylthiopyrimidine-5-amine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4,6-Dichloro-2-propylthiopyrimidine-5-amine?

Yes. Every lot of 4,6-Dichloro-2-propylthiopyrimidine-5-amine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4,6-Dichloro-2-propylthiopyrimidine-5-amine be shipped internationally?

Yes. 4,6-Dichloro-2-propylthiopyrimidine-5-amine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.