Tramadol N-Oxide

About Tramadol N-Oxide

Tramadol N-Oxide is a metabolite or degradation product of Tramadol carrying the CAS registry number 147441-56-3. With the molecular formula C16H25NO3, it has a molar mass of 279.37 g/mol. Its systematic (IUPAC) name is 1-[(1S,2S)-2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]-N,N-dimethylmethanamine oxide. Alternative names: Tramadol N-xide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Tramadol, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Tramadol N-Oxide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Tramadol

View every impurity, metabolite and intermediate we list for Tramadol.

Tramadol impurities

Specifications & identifiers

Chemical identifiers
Product name	Tramadol N-Oxide
Catalogue No.	VQ-044860
CAS Number	147441-56-3
IUPAC name	1-[(1S,2S)-2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]-N,N-dimethylmethanamine oxide
Molecular formula	C₁₆H₂₅NO₃
Molecular weight	279.37 g/mol
Exact mass	279.1834
Grade	Reference Standard
HSN code	38229090
InChIKey	HBXKSXMNNGHBEA-GOEBONIOSA-N
SMILES	C[N+](C)(C[C@@H]1CCCC[C@]1(C2=CC(=CC=C2)OC)O)[O-]
PubChem CID	25271934

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	1 / 3
TPSA	47.5 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tramadol N-Oxide?

The CAS Registry Number of Tramadol N-Oxide is 147441-56-3. It is also known as [(1S,2S)-2-Hydroxy-2-(3-methoxyphenyl)cyclohexyl]-N,N-dimethylmethanamine N-oxide, Tramadol N-xide.

What is the molecular formula and molecular weight of Tramadol N-Oxide?

Tramadol N-Oxide has the molecular formula C16H25NO3 and a molecular weight of 279.37 g/mol. Its IUPAC name is 1-[(1S,2S)-2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]-N,N-dimethylmethanamine oxide.

What is Tramadol N-Oxide used for?

Tramadol N-Oxide is supplied as a characterised reference material related to Tramadol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tramadol N-Oxide can I order?

We supply Tramadol N-Oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tramadol N-Oxide?

Yes. Every lot of Tramadol N-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tramadol N-Oxide be shipped internationally?

Yes. Tramadol N-Oxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.