Sacubitril ethyl Impurity

About Sacubitril ethyl Impurity

Sacubitril ethyl Impurity is an impurity of Sacubitril carrying the CAS registry number 149709-59-1. With the molecular formula C25H31NO4, it has a molar mass of 409.5 g/mol. Its systematic (IUPAC) name is ethyl (E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoate. Alternative names: Sacubitril RC 2 and Valsartan Impurity 47.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Sacubitril to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sacubitril

View every impurity, metabolite and intermediate we list for Sacubitril.

Sacubitril impurities

Specifications & identifiers

Chemical identifiers
Product name	Sacubitril ethyl Impurity
Catalogue No.	VQ-027955
CAS Number	149709-59-1
IUPAC name	ethyl (E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoate
Molecular formula	C₂₅H₃₁NO₄
Molecular weight	409.5 g/mol
Exact mass	409.2253
Grade	Reference Standard
HSN code	38229090
InChIKey	QOCQMJHAWNNWAV-BKELBIJQSA-N
SMILES	CCOC(=O)/C(=C/[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)OC(C)(C)C)/C
PubChem CID	58027475

Physical properties
Physical form	Solid
LogP (XLogP3)	5.4
H-bond donors / acceptors	1 / 4
TPSA	64.6 Å²
Synonyms	Sacubitril RC 2, (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate, (R,E)-Ethyl 5-((1,1'-biphenyl)-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate, (R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate, Valsartan Impurity 47, Sacubitril Impurity C32, LCZ-696 Impurity 22, ethyl (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate, 4X-169622CZ-696 Impurity 93, (E)-(R)-5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid ethyl ester, (R)-Ethyl5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate, ethyl (2E,4R)-4-{[(tert-butoxy)carbonyl]amino}-2-methyl-5-(4-phenylphenyl)pent-2-enoate

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sacubitril ethyl Impurity?

The CAS Registry Number of Sacubitril ethyl Impurity is 149709-59-1. It is also known as Sacubitril RC 2, (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate, (R,E)-Ethyl 5-((1,1'-biphenyl)-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate.

What is the molecular formula and molecular weight of Sacubitril ethyl Impurity?

Sacubitril ethyl Impurity has the molecular formula C25H31NO4 and a molecular weight of 409.5 g/mol. Its IUPAC name is ethyl (E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoate.

What is Sacubitril ethyl Impurity used for?

Sacubitril ethyl Impurity is supplied as a characterised reference material related to Sacubitril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sacubitril ethyl Impurity can I order?

We supply Sacubitril ethyl Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sacubitril ethyl Impurity?

Yes. Every lot of Sacubitril ethyl Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sacubitril ethyl Impurity be shipped internationally?

Yes. We export Sacubitril ethyl Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.