2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin… 152460-09-8

Name: 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine
Brand: Vaqora Chemicals
SKU: VQ-037670

About 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine

2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine is a nitrosamine impurity of Imatinib carrying the CAS registry number 152460-09-8. Its molecular formula is C16H13N5O2 and its molecular weight is 307.31 g/mol. Systematically, it is named N-(2-methyl-5-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Imatinib

View every impurity, metabolite and intermediate we list for Imatinib.

Imatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine
Catalogue No.	VQ-037670
CAS Number	152460-09-8
IUPAC name	N-(2-methyl-5-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine
Molecular formula	C₁₆H₁₃N₅O₂
Molecular weight	307.31 g/mol
Exact mass	307.1069
Grade	Reference Standard
HSN code	38229090
InChIKey	OJITWRFPRCHSMX-UHFFFAOYSA-N
SMILES	CC1=C(C=C(C=C1)[N+](=O)[O-])NC2=NC=CC(=N2)C3=CN=CC=C3
PubChem CID	10686149

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	1 / 6
TPSA	96.5 Å²
Synonyms	2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine, N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine, N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine, 2-Pyrimidinamine, N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-, N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine, n-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidineamine, N-(2-methyl-5-nitro-phenyl)-4-(3-pyridyl)pyrimidin-2-amine, 2-(2-methyl-5-nitroanilino)-4-(3-pyridinyl)pyrimidine, N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-pyrimidine-amine, 2-[(2-Methyl-5-nitrophenyl)amino]-4-(3-pyridyl)pyrimidine, N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine, N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine?

The CAS Registry Number of 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine is 152460-09-8. It is also known as 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine, N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine, N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine.

What is the molecular formula and molecular weight of 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine?

2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine has the molecular formula C16H13N5O2 and a molecular weight of 307.31 g/mol. Its IUPAC name is N-(2-methyl-5-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine.

What is 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine used for?

2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine is supplied as a characterised reference material related to Imatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine can I order?

We supply 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine?

Yes. Every lot of 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine be shipped internationally?

Yes. 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.