Metoprolol EP Impurity O

About Metoprolol EP Impurity O

Metoprolol EP Impurity O is a pharmacopeial impurity of Metoprolol carrying the CAS registry number 154784-36-8. Formula C27H41NO6, molecular weight 475.6 g/mol. Its systematic (IUPAC) name is 1-[[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-propan-2-ylamino]-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol. Alternative names: Metoprolol Tartrate - Impurity O and Metoprolol Succinate - Impurity O.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Metoprolol, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Metoprolol

View every impurity, metabolite and intermediate we list for Metoprolol.

Metoprolol impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Metoprolol EP Impurity O
Catalogue No.	VQ-026664
CAS Number	154784-36-8
IUPAC name	1-[[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-propan-2-ylamino]-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
Molecular formula	C₂₇H₄₁NO₆
Molecular weight	475.6 g/mol
Exact mass	475.2934
Grade	Reference Standard
HSN code	38229090
InChIKey	FPFJXNCXQDHWGC-UHFFFAOYSA-N
SMILES	CC(C)N(CC(COC1=CC=C(C=C1)CCOC)O)CC(COC2=CC=C(C=C2)CCOC)O
PubChem CID	46782247

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	2 / 7
TPSA	80.6 Å²
Synonyms	Metoprolol Tartrate - Impurity O, Metoprolol Succinate - Impurity O, 1,1'-((1-Methylethyl)imino)bis(3-(4-(2-methoxyethyl)phenoxy)propan-2-ol), 1,1'-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]propan-2-ol], Metoprolol tartrate specified impurity O, Metoprolol succinate specified impurity O, (+/-)-N,N-Bis(2-hydroxy-3-(4-(2-methoxyethyl)phenoxy)propyl)(1-methylethyl)amine, 3,3'-(Isopropylazanediyl)bis(1-(4-(2-methoxyethyl)phenoxy)propan-2-ol), Metoprolol Tartrate impurity O, 3,3'-(Isopropylimino)bis{1-[4-(2-methoxyethyl)phenoxy]-2-propanol}

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Metoprolol EP Impurity O?

The CAS Registry Number of Metoprolol EP Impurity O is 154784-36-8. It is also known as Metoprolol Tartrate - Impurity O, Metoprolol Succinate - Impurity O, 1,1'-((1-Methylethyl)imino)bis(3-(4-(2-methoxyethyl)phenoxy)propan-2-ol).

What is the molecular formula and molecular weight of Metoprolol EP Impurity O?

Metoprolol EP Impurity O has the molecular formula C27H41NO6 and a molecular weight of 475.6 g/mol. Its IUPAC name is 1-[[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-propan-2-ylamino]-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol.

What is Metoprolol EP Impurity O used for?

Metoprolol EP Impurity O is supplied as a characterised reference material related to Metoprolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Metoprolol EP Impurity O can I order?

We supply Metoprolol EP Impurity O in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Metoprolol EP Impurity O?

Yes. Every lot of Metoprolol EP Impurity O is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Metoprolol EP Impurity O be shipped internationally?

Yes. Metoprolol EP Impurity O is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.