(S)-Isotimolol

Name: (S)-Isotimolol
Brand: Vaqora Chemicals
SKU: VQ-028392

About (S)-Isotimolol

(S)-Isotimolol (CAS 158636-96-5) is an impurity of Timolol offered by Vaqora Chemicals. Formula C13H24N4O3S, molecular weight 316.42 g/mol. Its systematic (IUPAC) name is (2S)-3-(tert-butylamino)-2-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-1-ol.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Timolol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies (S)-Isotimolol in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Timolol

View every impurity, metabolite and intermediate we list for Timolol.

Timolol impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-Isotimolol
Catalogue No.	VQ-028392
CAS Number	158636-96-5
IUPAC name	(2S)-3-(tert-butylamino)-2-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-1-ol
Molecular formula	C₁₃H₂₄N₄O₃S
Molecular weight	316.42 g/mol
Exact mass	316.1569
Grade	Reference Standard
HSN code	38229090
InChIKey	MAMSPDKEMJALRZ-JTQLQIEISA-N
SMILES	CC(C)(C)NC[C@@H](CO)OC1=NSN=C1N2CCOCC2
PubChem CID	76969234

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	2 / 8
TPSA	108 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P264, P270, P301 + P317, P319, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-Isotimolol?

The CAS Registry Number of (S)-Isotimolol is 158636-96-5. It is also known as (S)-2-(tert.-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-1-propanol, (S)-2-(tert.-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-1-propanol, (S)-3-(tert-Butylamino)-2-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-1-ol.

What is the molecular formula and molecular weight of (S)-Isotimolol?

(S)-Isotimolol has the molecular formula C13H24N4O3S and a molecular weight of 316.42 g/mol. Its IUPAC name is (2S)-3-(tert-butylamino)-2-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-1-ol.

What is (S)-Isotimolol used for?

(S)-Isotimolol is supplied as a characterised reference material related to Timolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-Isotimolol can I order?

We supply (S)-Isotimolol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-Isotimolol?

Yes. Every lot of (S)-Isotimolol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-Isotimolol be shipped internationally?

Yes. (S)-Isotimolol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.