N-Nitrosonornicotine

Name: N-Nitrosonornicotine
Brand: Vaqora Chemicals
SKU: VQ-032142

About N-Nitrosonornicotine

N-Nitrosonornicotine (CAS 16543-55-8) is a nitrosamine impurity of Nicotine offered by Vaqora Chemicals. Formula C9H11N3O, molecular weight 177.2 g/mol. Systematically, it is named 3-[(2S)-1-nitrosopyrrolidin-2-yl]pyridine. Alternative names: (S)-3-(1-Nitrosopyrrolidin-2-yl)pyridine and (2S)-N`-Nitrosonornicotine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Nicotine

View every impurity, metabolite and intermediate we list for Nicotine.

Nicotine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitrosonornicotine
Catalogue No.	VQ-032142
CAS Number	16543-55-8
IUPAC name	3-[(2S)-1-nitrosopyrrolidin-2-yl]pyridine
Molecular formula	C₉H₁₁N₃O
Molecular weight	177.2 g/mol
Exact mass	177.0902
Grade	Reference Standard
HSN code	38229090
InChIKey	XKABJYQDMJTNGQ-VIFPVBQESA-N
SMILES	C1C[C@H](N(C1)N=O)C2=CN=CC=C2
PubChem CID	12613538

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	0 / 4
TPSA	45.6 Å²
Synonyms	(S)-3-(1-Nitrosopyrrolidin-2-yl)pyridine, (2S)-N`-Nitrosonornicotine, Nitrosonornicotine, 1'-Nitrosonornicotine, anti-N'-Nitrosonornicotine, Nicotine, 1'-demethyl-1'-nitroso-, 1'-Demethyl-1'-nitrosonicotine, 1'-Nitroso-1'-demethylnicotine, 1'-Desmethyl-1'-nitrosonicotine, (S)-N'-Nitrosonornicotine, 1-Nitroso-2-(3-pyridyl)pyrrolidine

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitrosonornicotine?

The CAS Registry Number of N-Nitrosonornicotine is 16543-55-8. It is also known as (S)-3-(1-Nitrosopyrrolidin-2-yl)pyridine, (2S)-N`-Nitrosonornicotine, Nitrosonornicotine.

What is the molecular formula and molecular weight of N-Nitrosonornicotine?

N-Nitrosonornicotine has the molecular formula C9H11N3O and a molecular weight of 177.2 g/mol. Its IUPAC name is 3-[(2S)-1-nitrosopyrrolidin-2-yl]pyridine.

What is N-Nitrosonornicotine used for?

N-Nitrosonornicotine is supplied as a characterised reference material related to Nicotine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitrosonornicotine can I order?

We supply N-Nitrosonornicotine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitrosonornicotine?

Yes. Every lot of N-Nitrosonornicotine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitrosonornicotine be shipped internationally?

Yes. N-Nitrosonornicotine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.