6-Keto Nalbuphine

Name: 6-Keto Nalbuphine
Brand: Vaqora Chemicals
SKU: VQ-032058

About 6-Keto Nalbuphine

6-Keto Nalbuphine (CAS 16676-33-8) is an impurity of Nalbuphine offered by Vaqora Chemicals. The compound has the formula C21H25NO4, corresponding to a molecular weight of 355.4 g/mol. Alternative names: Nalbuphone and 6-Keto Nalbuphine (Free Base).

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Nalbuphine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nalbuphine

View every impurity, metabolite and intermediate we list for Nalbuphine.

Nalbuphine impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Keto Nalbuphine
Catalogue No.	VQ-032058
CAS Number	16676-33-8
IUPAC name	(4R,4aS,7aR,12bS)-3-(cyclobutylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formula	C₂₁H₂₅NO₄
Molecular weight	355.4 g/mol
Exact mass	355.1784
Grade	Reference Standard
HSN code	38229090
InChIKey	VANAVLBJMFLURS-MBPVOVBZSA-N
SMILES	C1CC(C1)CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
PubChem CID	44465003

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	2 / 5
TPSA	70 Å²
Synonyms	Nalbuphone, 6-Keto Nalbuphine (Free Base), N-(cyclobutylmethyl)-noroxymorphone, (5alpha)-17-(Cyclobutylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one, 17-(Cyclobutylmethyl)-3,14-dihydroxy-5alpha-4,5-epoxymorphinan-6-one

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H317May cause an allergic skin reaction
H331Toxic if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H336May cause drowsiness or dizziness

Precautionary statements: P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301 + P316, P302 + P352, P304 + P340, P316, P319, P321, P330, P333 + P317, P342 + P316, P361 + P364, P362 + P364, P403, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Keto Nalbuphine?

The CAS Registry Number of 6-Keto Nalbuphine is 16676-33-8. It is also known as Nalbuphone, 6-Keto Nalbuphine (Free Base), N-(cyclobutylmethyl)-noroxymorphone.

What is the molecular formula and molecular weight of 6-Keto Nalbuphine?

6-Keto Nalbuphine has the molecular formula C21H25NO4 and a molecular weight of 355.4 g/mol. Its IUPAC name is (4R,4aS,7aR,12bS)-3-(cyclobutylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one.

What is 6-Keto Nalbuphine used for?

6-Keto Nalbuphine is supplied as a characterised reference material related to Nalbuphine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Keto Nalbuphine can I order?

We supply 6-Keto Nalbuphine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Keto Nalbuphine?

Yes. Every lot of 6-Keto Nalbuphine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Keto Nalbuphine be shipped internationally?

Yes. 6-Keto Nalbuphine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.