4-Hydroxy Antipyrine

Name: 4-Hydroxy Antipyrine
Brand: Vaqora Chemicals
SKU: VQ-027115

About 4-Hydroxy Antipyrine

4-Hydroxy Antipyrine (CAS 1672-63-5) is a metabolite or degradation product of Metamizole offered by Vaqora Chemicals. Its molecular formula is C11H12N2O2 and its molecular weight is 204.22 g/mol. The IUPAC name is 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one. Alternative names: Antipyrine, 4-hydroxy and 4-hydroxyphenazone.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Metamizole, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 4-Hydroxy Antipyrine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Metamizole

View every impurity, metabolite and intermediate we list for Metamizole.

Metamizole impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy Antipyrine
Catalogue No.	VQ-027115
CAS Number	1672-63-5
IUPAC name	4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one
Molecular formula	C₁₁H₁₂N₂O₂
Molecular weight	204.22 g/mol
Exact mass	204.0899
Grade	Reference Standard
HSN code	38229090
InChIKey	SKVPTPMWXJSBTF-UHFFFAOYSA-N
SMILES	CC1=C(C(=O)N(N1C)C2=CC=CC=C2)O
PubChem CID	98889

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	1 / 3
TPSA	43.8 Å²
Synonyms	3H-Pyrazol-3-one, 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-, 4-Hydroxy-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, Antipyrine, 4-hydroxy, 4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one, 4-hydroxyphenazone, 4-Hydroxyantipyrene, 1,2-Dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, 4-hydroxy-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one, 4-hydroxy-1,5-dimethyl-2-phenyl-3-pyrazolone, 4-hydroxy-1,5-dimethyl-2-phenyl-pyrazol-3-one, 3H-Pyrazol-3-one,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy Antipyrine?

The CAS Registry Number of 4-Hydroxy Antipyrine is 1672-63-5. It is also known as 3H-Pyrazol-3-one, 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-, 4-Hydroxy-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, Antipyrine, 4-hydroxy.

What is the molecular formula and molecular weight of 4-Hydroxy Antipyrine?

4-Hydroxy Antipyrine has the molecular formula C11H12N2O2 and a molecular weight of 204.22 g/mol. Its IUPAC name is 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one.

What is 4-Hydroxy Antipyrine used for?

4-Hydroxy Antipyrine is supplied as a characterised reference material related to Metamizole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy Antipyrine can I order?

We supply 4-Hydroxy Antipyrine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy Antipyrine?

Yes. Every lot of 4-Hydroxy Antipyrine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy Antipyrine be shipped internationally?

Yes. 4-Hydroxy Antipyrine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.