Carbidopa EP Impurity B

About Carbidopa EP Impurity B

Carbidopa EP Impurity B is a pharmacopeial impurity of Carbidopa carrying the CAS registry number 18181-08-3. The compound has the formula C11H15NO4, corresponding to a molecular weight of 225.24 g/mol. The IUPAC name is methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate. Common synonyms include α-Methyldopa Methyl Ester and Methyldopa Methyl Ester.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Carbidopa, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Carbidopa EP Impurity B is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Carbidopa

View every impurity, metabolite and intermediate we list for Carbidopa.

Carbidopa impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Carbidopa EP Impurity B
Catalogue No.	VQ-022002
CAS Number	18181-08-3
IUPAC name	methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
Molecular formula	C₁₁H₁₅NO₄
Molecular weight	225.24 g/mol
Exact mass	225.1001
Grade	Reference Standard
HSN code	38229090
InChIKey	MKFJJXIMFTXSEM-NSHDSACASA-N
SMILES	C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)OC)N
PubChem CID	28934

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	3 / 5
TPSA	92.8 Å²
Synonyms	α-Methyldopa Methyl Ester, Methyldopa Methyl Ester, Carbidopa Impurity B, Carbidopa - Impurity B, 3-Hydroxy-alpha-methyl-L-tyrosine methyl ester, Alpha-methyl-melevodopa, alpha-Methyldopa methyl ester, a-Methyldopa Methyl Ester, Methyl (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate, alpha-Methyl-3,4-dihydroxy-L-phenylalanine methyl ester, L-3-(3,4-Dihydroxyphenyl)-2-methylalanine methyl ester

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P321, P330, P332 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Carbidopa EP Impurity B?

The CAS Registry Number of Carbidopa EP Impurity B is 18181-08-3. It is also known as α-Methyldopa Methyl Ester, Methyldopa Methyl Ester, Carbidopa Impurity B.

What is the molecular formula and molecular weight of Carbidopa EP Impurity B?

Carbidopa EP Impurity B has the molecular formula C11H15NO4 and a molecular weight of 225.24 g/mol. Its IUPAC name is methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate.

What is Carbidopa EP Impurity B used for?

Carbidopa EP Impurity B is supplied as a characterised reference material related to Carbidopa. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Carbidopa EP Impurity B can I order?

We supply Carbidopa EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Carbidopa EP Impurity B?

Yes. Every lot of Carbidopa EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Carbidopa EP Impurity B be shipped internationally?

Yes. Carbidopa EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.