Isoflurane EP Impurity B

About Isoflurane EP Impurity B

Isoflurane EP Impurity B is a pharmacopeial impurity of Isoflurane carrying the CAS registry number 1885-48-9. Its molecular formula is C3H3F5O and its molecular weight is 150.05 g/mol. The IUPAC name is 2-(difluoromethoxy)-1,1,1-trifluoroethane. Alternative names: Isoflurane - Impurity B and Difluoromethyl 2,2,2-trifluoroethyl ether.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Isoflurane, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Isoflurane

View every impurity, metabolite and intermediate we list for Isoflurane.

Isoflurane impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Isoflurane EP Impurity B
Catalogue No.	VQ-031257
CAS Number	1885-48-9
IUPAC name	2-(difluoromethoxy)-1,1,1-trifluoroethane
Molecular formula	C₃H₃F₅O
Molecular weight	150.05 g/mol
Exact mass	150.0104
Grade	Reference Standard
HSN code	38229090
InChIKey	ZASBKNPRLPFSCA-UHFFFAOYSA-N
SMILES	C(C(F)(F)F)OC(F)F
PubChem CID	74668

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	0 / 6
TPSA	9.2 Å²
Synonyms	Isoflurane - Impurity B, Difluoromethyl 2,2,2-trifluoroethyl ether, 2,2,2-Trifluoroethyl difluoromethyl ether, HFE-245MF, HFE-245fa2, HFC-E-245, R-E-245FA1, Ethane, 2-(difluoromethoxy)-1,1,1-trifluoro-, trifluoroethyl difluoromethyl ether, 2-difluoromethoxy-1,1,1-trifluoro-ethane, 2-(difluoromethoxy)-1,1,1-trifluoro-ethane, 2-(Difluoromethoxy)-1,1,1-trifluoroethane, 3-Oxa-1,1,1,4,4-pentafluorobutane

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Isoflurane EP Impurity B?

The CAS Registry Number of Isoflurane EP Impurity B is 1885-48-9. It is also known as Isoflurane - Impurity B, Difluoromethyl 2,2,2-trifluoroethyl ether, 2,2,2-Trifluoroethyl difluoromethyl ether.

What is the molecular formula and molecular weight of Isoflurane EP Impurity B?

Isoflurane EP Impurity B has the molecular formula C3H3F5O and a molecular weight of 150.05 g/mol. Its IUPAC name is 2-(difluoromethoxy)-1,1,1-trifluoroethane.

What is Isoflurane EP Impurity B used for?

Isoflurane EP Impurity B is supplied as a characterised reference material related to Isoflurane. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Isoflurane EP Impurity B can I order?

We supply Isoflurane EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Isoflurane EP Impurity B?

Yes. Every lot of Isoflurane EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Isoflurane EP Impurity B be shipped internationally?

Yes. Isoflurane EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.