(S)-Propane-1,2-diamine dihydrochloride

About (S)-Propane-1,2-diamine dihydrochloride

(S)-Propane-1,2-diamine dihydrochloride is an impurity of Encorafenib carrying the CAS registry number 19777-66-3. Formula C3H12Cl2N2, molecular weight 147.04 g/mol. It is also known as (2S)-propane-1,2-diamine dihydrochloride or (S)-(-)-1,2-Diaminopropane dihydrochloride.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Encorafenib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer (S)-Propane-1,2-diamine dihydrochloride in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Encorafenib

View every impurity, metabolite and intermediate we list for Encorafenib.

Encorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-Propane-1,2-diamine dihydrochloride
Catalogue No.	VQ-048211
CAS Number	19777-66-3
IUPAC name	(2S)-propane-1,2-diamine;dihydrochloride
Molecular formula	C₃H₁₂Cl₂N₂
Molecular weight	147.04 g/mol
Exact mass	146.0378
Grade	Reference Standard
HSN code	38229090
InChIKey	AEIAMRMQKCPGJR-QTNFYWBSSA-N
SMILES	C[C@@H](CN)N.Cl.Cl
PubChem CID	12217445

Physical properties
Physical form	Solid
H-bond donors / acceptors	4 / 2
TPSA	52 Å²
Synonyms	(2S)-propane-1,2-diamine dihydrochloride, (S)-(-)-1,2-Diaminopropane dihydrochloride, (S)-1,2-Diaminopropane Dihydrochloride, (S)-1,2-Propanediamine dihydrochloride, 1,2-Propanediamine, hydrochloride (1:2), (2S)-, (S)-1,2-Diaminopropane 2HCl, S-(-)-propylenediamine dihydrochloride, 1,2-Propanediamine, dihydrochloride, (S)-, (S)-Propylenediamine Dihydrochloride, (s)-1,2-diaminopropane dihydrochlo-ride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-Propane-1,2-diamine dihydrochloride?

The CAS Registry Number of (S)-Propane-1,2-diamine dihydrochloride is 19777-66-3. It is also known as (2S)-propane-1,2-diamine dihydrochloride, (S)-(-)-1,2-Diaminopropane dihydrochloride, (S)-1,2-Diaminopropane Dihydrochloride.

What is the molecular formula and molecular weight of (S)-Propane-1,2-diamine dihydrochloride?

(S)-Propane-1,2-diamine dihydrochloride has the molecular formula C3H12Cl2N2 and a molecular weight of 147.04 g/mol.

What is (S)-Propane-1,2-diamine dihydrochloride used for?

(S)-Propane-1,2-diamine dihydrochloride is supplied as a characterised reference material related to Encorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-Propane-1,2-diamine dihydrochloride can I order?

We supply (S)-Propane-1,2-diamine dihydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-Propane-1,2-diamine dihydrochloride?

Yes. Every lot of (S)-Propane-1,2-diamine dihydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-Propane-1,2-diamine dihydrochloride be shipped internationally?

Yes. (S)-Propane-1,2-diamine dihydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.