Ibrutinib N7-Oxide Impurity

About Ibrutinib N7-Oxide Impurity

Ibrutinib N7-Oxide Impurity is an impurity of Ibrutinib carrying the CAS registry number 2052279-49-7. Formula C25H24N6O3, molecular weight 456.5 g/mol. The IUPAC name is 1-[(3R)-3-[7-hydroxy-4-imino-3-(4-phenoxyphenyl)pyrazolo[5,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one. Common synonyms include Ibrutinib Impurity-35.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Ibrutinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Ibrutinib

View every impurity, metabolite and intermediate we list for Ibrutinib.

Ibrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Ibrutinib N7-Oxide Impurity
Catalogue No.	VQ-005094
CAS Number	2052279-49-7
IUPAC name	1-[(3R)-3-[7-hydroxy-4-imino-3-(4-phenoxyphenyl)pyrazolo[5,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
Molecular formula	C₂₅H₂₄N₆O₃
Molecular weight	456.5 g/mol
Exact mass	456.191
Grade	Reference Standard
HSN code	38229090
InChIKey	CXADSVNGJZSUEA-GOSISDBHSA-N
SMILES	C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=N)N=CN3O
PubChem CID	163202529

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	2 / 5
TPSA	107 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ibrutinib N7-Oxide Impurity?

The CAS Registry Number of Ibrutinib N7-Oxide Impurity is 2052279-49-7. It is also known as Ibrutinib Impurity-35.

What is the molecular formula and molecular weight of Ibrutinib N7-Oxide Impurity?

Ibrutinib N7-Oxide Impurity has the molecular formula C25H24N6O3 and a molecular weight of 456.5 g/mol. Its IUPAC name is 1-[(3R)-3-[7-hydroxy-4-imino-3-(4-phenoxyphenyl)pyrazolo[5,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one.

What is Ibrutinib N7-Oxide Impurity used for?

Ibrutinib N7-Oxide Impurity is supplied as a characterised reference material related to Ibrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ibrutinib N7-Oxide Impurity can I order?

We supply Ibrutinib N7-Oxide Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ibrutinib N7-Oxide Impurity?

Yes. Every lot of Ibrutinib N7-Oxide Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ibrutinib N7-Oxide Impurity be shipped internationally?

Yes. We export Ibrutinib N7-Oxide Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.