4-Chloro-N-methyl-2-pyridinecarboxamide

About 4-Chloro-N-methyl-2-pyridinecarboxamide

4-Chloro-N-methyl-2-pyridinecarboxamide is an impurity of Sorafenib carrying the CAS registry number 220000-87-3. Formula C7H7ClN2O, molecular weight 170.59 g/mol. Its systematic (IUPAC) name is 4-chloro-N-methylpyridine-2-carboxamide. Alternative names: 4-Chloro-N-methylpicolinamide and N-Methyl-4-chloropyridine-2-carboxamide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Sorafenib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-Chloro-N-methyl-2-pyridinecarboxamide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sorafenib

View every impurity, metabolite and intermediate we list for Sorafenib.

Sorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Chloro-N-methyl-2-pyridinecarboxamide
Catalogue No.	VQ-033924
CAS Number	220000-87-3
IUPAC name	4-chloro-N-methylpyridine-2-carboxamide
Molecular formula	C₇H₇ClN₂O
Molecular weight	170.59 g/mol
Exact mass	170.0247
Grade	Reference Standard
HSN code	38229090
InChIKey	BGVBBMZMEKXUTR-UHFFFAOYSA-N
SMILES	CNC(=O)C1=NC=CC(=C1)Cl
PubChem CID	1476814

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	1 / 2
TPSA	42 Å²
Synonyms	4-Chloro-N-methylpicolinamide, N-Methyl-4-chloropyridine-2-carboxamide, 2-Pyridinecarboxamide, 4-chloro-N-methyl-, (4-chloro(2-pyridyl))-N-methylcarboxamide, 4-Chloranyl-~{n}-Methyl-Pyridine-2-Carboxamide, 4-chloro-pyridine-2-carboxylic acid methyl amide, 4-chloro-N-Methylpyridine-2-carboxamide, AldrichCPR, 4-Chloro-N-methylpyridine-2-carboxamide (>90per cent), 7MU, 4-chloro-N-methyl-pyridine-2-carboxamide, N-methyl4-chloropicolinamide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Chloro-N-methyl-2-pyridinecarboxamide?

The CAS Registry Number of 4-Chloro-N-methyl-2-pyridinecarboxamide is 220000-87-3. It is also known as 4-Chloro-N-methylpicolinamide, N-Methyl-4-chloropyridine-2-carboxamide, 2-Pyridinecarboxamide, 4-chloro-N-methyl-.

What is the molecular formula and molecular weight of 4-Chloro-N-methyl-2-pyridinecarboxamide?

4-Chloro-N-methyl-2-pyridinecarboxamide has the molecular formula C7H7ClN2O and a molecular weight of 170.59 g/mol. Its IUPAC name is 4-chloro-N-methylpyridine-2-carboxamide.

What is 4-Chloro-N-methyl-2-pyridinecarboxamide used for?

4-Chloro-N-methyl-2-pyridinecarboxamide is supplied as a characterised reference material related to Sorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Chloro-N-methyl-2-pyridinecarboxamide can I order?

We supply 4-Chloro-N-methyl-2-pyridinecarboxamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Chloro-N-methyl-2-pyridinecarboxamide?

Yes. Every lot of 4-Chloro-N-methyl-2-pyridinecarboxamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Chloro-N-methyl-2-pyridinecarboxamide be shipped internationally?

Yes. 4-Chloro-N-methyl-2-pyridinecarboxamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.