2-Hydroxy-3,5-diisopropylbenzoic acid

About 2-Hydroxy-3,5-diisopropylbenzoic acid

2-Hydroxy-3,5-diisopropylbenzoic acid is an impurity of Propofol carrying the CAS registry number 2215-21-6. With the molecular formula C13H18O3, it has a molar mass of 222.28 g/mol. The IUPAC name is 2-hydroxy-3,5-di(propan-2-yl)benzoic acid. Alternative names: 3,5-Diisopropylsalicylic acid and 3,5-Diisopropylsalicylate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Propofol, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 2-Hydroxy-3,5-diisopropylbenzoic acid in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Propofol

View every impurity, metabolite and intermediate we list for Propofol.

Propofol impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Hydroxy-3,5-diisopropylbenzoic acid
Catalogue No.	VQ-033373
CAS Number	2215-21-6
IUPAC name	2-hydroxy-3,5-di(propan-2-yl)benzoic acid
Molecular formula	C₁₃H₁₈O₃
Molecular weight	222.28 g/mol
Exact mass	222.1256
Grade	Reference Standard
HSN code	38229090
InChIKey	XUFUYOGWFZSHGE-UHFFFAOYSA-N
SMILES	CC(C)C1=CC(=C(C(=C1)C(=O)O)O)C(C)C
PubChem CID	30543

Physical properties
Physical form	Solid
LogP (XLogP3)	5.5
H-bond donors / acceptors	2 / 3
TPSA	57.5 Å²
Synonyms	3,5-Diisopropylsalicylic acid, 3,5-Diisopropylsalicylate, Benzoic acid, 2-hydroxy-3,5-bis(1-methylethyl)-, 3,5-Diisopropyl-2-hydroxybenzoic acid, 2-hydroxy-3,5-bis(propan-2-yl)benzoic acid, 3,5-di-iso-Propyl-2-hydroxybenzoic acid, 3,5-Bis(isopropyl)-2-hydroxybenzoic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Hydroxy-3,5-diisopropylbenzoic acid?

The CAS Registry Number of 2-Hydroxy-3,5-diisopropylbenzoic acid is 2215-21-6. It is also known as 3,5-Diisopropylsalicylic acid, 3,5-Diisopropylsalicylate, Benzoic acid, 2-hydroxy-3,5-bis(1-methylethyl)-.

What is the molecular formula and molecular weight of 2-Hydroxy-3,5-diisopropylbenzoic acid?

2-Hydroxy-3,5-diisopropylbenzoic acid has the molecular formula C13H18O3 and a molecular weight of 222.28 g/mol. Its IUPAC name is 2-hydroxy-3,5-di(propan-2-yl)benzoic acid.

What is 2-Hydroxy-3,5-diisopropylbenzoic acid used for?

2-Hydroxy-3,5-diisopropylbenzoic acid is supplied as a characterised reference material related to Propofol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Hydroxy-3,5-diisopropylbenzoic acid can I order?

We supply 2-Hydroxy-3,5-diisopropylbenzoic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Hydroxy-3,5-diisopropylbenzoic acid?

Yes. Every lot of 2-Hydroxy-3,5-diisopropylbenzoic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Hydroxy-3,5-diisopropylbenzoic acid be shipped internationally?

Yes. 2-Hydroxy-3,5-diisopropylbenzoic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.