Clobetasol Propionate EP Impurity G

Name: Clobetasol Propionate EP Impurity G
Brand: Vaqora Chemicals
SKU: VQ-020700

About Clobetasol Propionate EP Impurity G

Listed under CAS 25122-41-2, Clobetasol Propionate EP Impurity G is a pharmacopeial impurity of Betamethasone available from Vaqora Chemicals. The compound has the formula C22H28ClFO4, corresponding to a molecular weight of 410.9 g/mol. Common synonyms include Clobetasol and Betamethasone EP Impurity B.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Betamethasone impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Clobetasol Propionate EP Impurity G in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Betamethasone

View every impurity, metabolite and intermediate we list for Betamethasone.

Betamethasone impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Clobetasol Propionate EP Impurity G
Catalogue No.	VQ-020700
CAS Number	25122-41-2
IUPAC name	(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Molecular formula	C₂₂H₂₈ClFO₄
Molecular weight	410.9 g/mol
Exact mass	410.166
Grade	Reference Standard
HSN code	38229090
InChIKey	FCSHDIVRCWTZOX-DVTGEIKXSA-N
SMILES	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
PubChem CID	5311051

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	2 / 5
TPSA	74.6 Å²
Synonyms	Clobetasol, Betamethasone EP Impurity B, Betamethasone - Impurity B, Clobetasol Propionate - Impurity G, Clobecort Amex, 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione, (11beta,16beta)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, (11, _,16, _)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11,17-dihydroxy-16-methyl-, (11, A,16

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P260, P273, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Clobetasol Propionate EP Impurity G?

The CAS Registry Number of Clobetasol Propionate EP Impurity G is 25122-41-2. It is also known as Clobetasol, Betamethasone EP Impurity B, Betamethasone - Impurity B.

What is the molecular formula and molecular weight of Clobetasol Propionate EP Impurity G?

Clobetasol Propionate EP Impurity G has the molecular formula C22H28ClFO4 and a molecular weight of 410.9 g/mol. Its IUPAC name is (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one.

What is Clobetasol Propionate EP Impurity G used for?

Clobetasol Propionate EP Impurity G is supplied as a characterised reference material related to Betamethasone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Clobetasol Propionate EP Impurity G can I order?

We supply Clobetasol Propionate EP Impurity G in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Clobetasol Propionate EP Impurity G?

Yes. Every lot of Clobetasol Propionate EP Impurity G is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Clobetasol Propionate EP Impurity G be shipped internationally?

Yes. Clobetasol Propionate EP Impurity G is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.