2,2'-Dithiobis[N-methyl-benzamide]

About 2,2'-Dithiobis[N-methyl-benzamide]

2,2'-Dithiobis[N-methyl-benzamide] is an impurity of Axitinib carrying the CAS registry number 2527-58-4. With the molecular formula C16H16N2O2S2, it has a molar mass of 332.4 g/mol. Systematically, it is named N-methyl-2-[[2-(methylcarbamoyl)phenyl]disulfanyl]benzamide. Alternative names: Dithio-2,2'-bis(N-methylbenzamide) and 2,2'-disulfanediylbis(N-methylbenzamide).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Axitinib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Axitinib

View every impurity, metabolite and intermediate we list for Axitinib.

Axitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	2,2'-Dithiobis[N-methyl-benzamide]
Catalogue No.	VQ-029314
CAS Number	2527-58-4
IUPAC name	N-methyl-2-[[2-(methylcarbamoyl)phenyl]disulfanyl]benzamide
Molecular formula	C₁₆H₁₆N₂O₂S₂
Molecular weight	332.4 g/mol
Exact mass	332.0653
Grade	Reference Standard
HSN code	38229090
InChIKey	JEVCLNJEBFWVPD-UHFFFAOYSA-N
SMILES	CNC(=O)C1=CC=CC=C1SSC2=CC=CC=C2C(=O)NC
PubChem CID	75662

Physical properties
Physical form	Solid
LogP (XLogP3)	2.6
H-bond donors / acceptors	2 / 4
TPSA	109 Å²
Synonyms	Dithio-2,2'-bis(N-methylbenzamide), 2,2'-disulfanediylbis(N-methylbenzamide), N-methyl-2-[2-(methylcarbamoyl)phenyl]disulfanylbenzamide, 2,2'-Dithiobis[N-methylbenzamid], 2,2'-dithiobis[n-methyl-benzamid]

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H317May cause an allergic skin reaction
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P261, P272, P273, P280, P302 + P352, P321, P333 + P317, P362 + P364, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2,2'-Dithiobis[N-methyl-benzamide]?

The CAS Registry Number of 2,2'-Dithiobis[N-methyl-benzamide] is 2527-58-4. It is also known as Dithio-2,2'-bis(N-methylbenzamide), 2,2'-disulfanediylbis(N-methylbenzamide), N-methyl-2-[2-(methylcarbamoyl)phenyl]disulfanylbenzamide.

What is the molecular formula and molecular weight of 2,2'-Dithiobis[N-methyl-benzamide]?

2,2'-Dithiobis[N-methyl-benzamide] has the molecular formula C16H16N2O2S2 and a molecular weight of 332.4 g/mol. Its IUPAC name is N-methyl-2-[[2-(methylcarbamoyl)phenyl]disulfanyl]benzamide.

What is 2,2'-Dithiobis[N-methyl-benzamide] used for?

2,2'-Dithiobis[N-methyl-benzamide] is supplied as a characterised reference material related to Axitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2,2'-Dithiobis[N-methyl-benzamide] can I order?

We supply 2,2'-Dithiobis[N-methyl-benzamide] in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2,2'-Dithiobis[N-methyl-benzamide]?

Yes. Every lot of 2,2'-Dithiobis[N-methyl-benzamide] is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2,2'-Dithiobis[N-methyl-benzamide] be shipped internationally?

Yes. 2,2'-Dithiobis[N-methyl-benzamide] is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.