N-Nitroso Duloxetine

Name: N-Nitroso Duloxetine
Brand: Vaqora Chemicals
SKU: VQ-025445

About N-Nitroso Duloxetine

Listed under CAS 2680527-91-5, N-Nitroso Duloxetine is a nitrosamine impurity of Duloxetine available from Vaqora Chemicals. Its molecular formula is C18H18N2O2S and its molecular weight is 326.4 g/mol. Its systematic (IUPAC) name is N-methyl-N-[(3S)-3-naphthalen-1-yloxy-3-thiophen-2-ylpropyl]nitrous amide. Common synonyms include N-Nitroso-Rac-Duloxetine and (S)-Duloxetine Nitroso.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 2 hazard statements. Review the Safety Data Sheet before use.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Duloxetine, method validation (AMV) and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Duloxetine

View every impurity, metabolite and intermediate we list for Duloxetine.

Duloxetine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Duloxetine
Catalogue No.	VQ-025445
CAS Number	2680527-91-5
IUPAC name	N-methyl-N-[(3S)-3-naphthalen-1-yloxy-3-thiophen-2-ylpropyl]nitrous amide
Molecular formula	C₁₈H₁₈N₂O₂S
Molecular weight	326.4 g/mol
Exact mass	326.1089
Grade	Reference Standard
HSN code	38229090
InChIKey	RPVCVCXTFJVSSY-KRWDZBQOSA-N
SMILES	CN(CC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32)N=O
PubChem CID	169490797

Physical properties
Physical form	Solid
LogP (XLogP3)	4.7
H-bond donors / acceptors	0 / 5
TPSA	70.1 Å²

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H351Suspected of causing cancer

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Duloxetine?

The CAS Registry Number of N-Nitroso Duloxetine is 2680527-91-5. It is also known as N-Nitroso-Rac-Duloxetine, (S)-Duloxetine Nitroso, (S)-N-methyl-N-(3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl)nitrous amide.

What is the molecular formula and molecular weight of N-Nitroso Duloxetine?

N-Nitroso Duloxetine has the molecular formula C18H18N2O2S and a molecular weight of 326.4 g/mol. Its IUPAC name is N-methyl-N-[(3S)-3-naphthalen-1-yloxy-3-thiophen-2-ylpropyl]nitrous amide.

What is N-Nitroso Duloxetine used for?

N-Nitroso Duloxetine is supplied as a characterised reference material related to Duloxetine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Duloxetine can I order?

We supply N-Nitroso Duloxetine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Duloxetine?

Yes. Every lot of N-Nitroso Duloxetine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Duloxetine be shipped internationally?

Yes. N-Nitroso Duloxetine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.