Etravirine

Name: Etravirine
Brand: Vaqora Chemicals
SKU: VQ-030632

About Etravirine

Listed under CAS 269055-15-4, Etravirine is a high-purity reference standard of Etravirine available from Vaqora Chemicals. The compound has the formula C20H15BrN6O, corresponding to a molecular weight of 435.3 g/mol. The IUPAC name is 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile. It is also known as TMC-125 or TMC 125.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Etravirine, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Etravirine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Etravirine

View every impurity, metabolite and intermediate we list for Etravirine.

Etravirine impurities

Specifications & identifiers

Chemical identifiers
Product name	Etravirine
Catalogue No.	VQ-030632
CAS Number	269055-15-4
IUPAC name	4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
Molecular formula	C₂₀H₁₅BrN₆O
Molecular weight	435.3 g/mol
Exact mass	434.0491
Grade	Reference Standard
HSN code	38229090
InChIKey	PYGWGZALEOIKDF-UHFFFAOYSA-N
SMILES	CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
PubChem CID	193962

Physical properties
Physical form	Solid
LogP (XLogP3)	4.5
H-bond donors / acceptors	2 / 7
TPSA	121 Å²
Synonyms	TMC-125, TMC 125, 4-((6-Amino-5-bromo-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile, 4-(6-Amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile, 4-(6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl)oxy-3,5-dimethylbenzonitrile, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-benzonitrile, Etravirine (TMC125), Benzonitrile,4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-, 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethyl-benzonitrile, Intelence(TM)

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H319Causes serious eye irritation
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P264, P264 + P265, P270, P273, P280, P301 + P317, P305 + P351 + P338, P330, P337 + P317, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Etravirine?

The CAS Registry Number of Etravirine is 269055-15-4. It is also known as TMC-125, TMC 125, 4-((6-Amino-5-bromo-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile.

What is the molecular formula and molecular weight of Etravirine?

Etravirine has the molecular formula C20H15BrN6O and a molecular weight of 435.3 g/mol. Its IUPAC name is 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile.

What is Etravirine used for?

Etravirine is supplied as a characterised reference material related to Etravirine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Etravirine can I order?

We supply Etravirine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Etravirine?

Yes. Every lot of Etravirine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Etravirine be shipped internationally?

Yes. Etravirine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.