Trimethoprim 1-N-oxide

Name: Trimethoprim 1-N-oxide
Brand: Vaqora Chemicals
SKU: VQ-034444

About Trimethoprim 1-N-oxide

Listed under CAS 27653-68-5, Trimethoprim 1-N-oxide is a metabolite or degradation product of Trimethoprim available from Vaqora Chemicals. The compound has the formula C14H18N4O4, corresponding to a molecular weight of 306.32 g/mol. Systematically, it is named 1-hydroxy-2-imino-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-amine. Alternative names: Trimethoprim N-Oxide 1 and 1-Oxide Trimethoprim.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Trimethoprim, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Trimethoprim 1-N-oxide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Trimethoprim

View every impurity, metabolite and intermediate we list for Trimethoprim.

Trimethoprim impurities

Specifications & identifiers

Chemical identifiers
Product name	Trimethoprim 1-N-oxide
Catalogue No.	VQ-034444
CAS Number	27653-68-5
IUPAC name	1-hydroxy-2-imino-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-amine
Molecular formula	C₁₄H₁₈N₄O₄
Molecular weight	306.32 g/mol
Exact mass	306.1328
Grade	Reference Standard
HSN code	38229090
InChIKey	XAYZHNKZSZREPH-UHFFFAOYSA-N
SMILES	COC1=CC(=CC(=C1OC)OC)CC2=CN(C(=N)N=C2N)O
PubChem CID	5244071

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	3 / 5
TPSA	113 Å²
Synonyms	Trimethoprim N-Oxide 1, 1-Oxide Trimethoprim, Trimethoprim N-oxide, Trimethoprim 1-oxide, 1-NO-Trimethoprim, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 1-oxide, 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-, 1-oxide, Trimethoprim-3-N-oxide

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trimethoprim 1-N-oxide?

The CAS Registry Number of Trimethoprim 1-N-oxide is 27653-68-5. It is also known as Trimethoprim N-Oxide 1, 1-Oxide Trimethoprim, Trimethoprim N-oxide.

What is the molecular formula and molecular weight of Trimethoprim 1-N-oxide?

Trimethoprim 1-N-oxide has the molecular formula C14H18N4O4 and a molecular weight of 306.32 g/mol. Its IUPAC name is 1-hydroxy-2-imino-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-amine.

What is Trimethoprim 1-N-oxide used for?

Trimethoprim 1-N-oxide is supplied as a characterised reference material related to Trimethoprim. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trimethoprim 1-N-oxide can I order?

We supply Trimethoprim 1-N-oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trimethoprim 1-N-oxide?

Yes. Every lot of Trimethoprim 1-N-oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trimethoprim 1-N-oxide be shipped internationally?

Yes. We export Trimethoprim 1-N-oxide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.