Estramustine

About Estramustine

Estramustine is a high-purity reference standard of Estradiol carrying the CAS registry number 2998-57-4. Its molecular formula is C23H31Cl2NO3 and its molecular weight is 440.4 g/mol. Alternative names: Leo-275 and LEO 275.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Estradiol standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Estramustine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Estradiol

View every impurity, metabolite and intermediate we list for Estradiol.

Estradiol impurities

Specifications & identifiers

Chemical identifiers
Product name	Estramustine
Catalogue No.	VQ-048272
CAS Number	2998-57-4
IUPAC name	[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate
Molecular formula	C₂₃H₃₁Cl₂NO₃
Molecular weight	440.4 g/mol
Exact mass	439.1681
Grade	Reference Standard
HSN code	38229090
InChIKey	FRPJXPJMRWBBIH-RBRWEJTLSA-N
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
PubChem CID	259331

Physical properties
Physical form	Solid
LogP (XLogP3)	4
H-bond donors / acceptors	1 / 3
TPSA	49.8 Å²
Synonyms	Leo-275, LEO 275, Leo275, Estradiol 3-(N,N-bis(2-chloroethyl)carbamate), 17beta-Estradiol 3-(bis(2-chloroethyl)carbamate), Estradiol 3-[bis(2-chloroethyl)carbamate], Estradiol 3-(bis(2-chloroethyl)carbamate), Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate], Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate), estra-1,3,5(10)-triene-3,17beta-diol, 3-[bis(2-chloroethyl)carbamate], estra-1,3,5(10)-triene-3,17beta-diol, 3-(bis(2-chloroethyl)carbamate), Estramustin Phosphate

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H351Suspected of causing cancer
H360May damage fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Estramustine?

The CAS Registry Number of Estramustine is 2998-57-4. It is also known as Leo-275, LEO 275, Leo275.

What is the molecular formula and molecular weight of Estramustine?

Estramustine has the molecular formula C23H31Cl2NO3 and a molecular weight of 440.4 g/mol. Its IUPAC name is [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate.

What is Estramustine used for?

Estramustine is supplied as a characterised reference material related to Estradiol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Estramustine can I order?

We supply Estramustine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Estramustine?

Yes. Every lot of Estramustine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Estramustine be shipped internationally?

Yes. Estramustine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.