Histamine-d4 Dihydrochloride

About Histamine-d4 Dihydrochloride

Histamine-d4 Dihydrochloride is a stable isotope labelled analogue related to Histamine carrying the CAS registry number 344299-48-5. Formula C5H9N3, molecular weight 115.17 g/mol. The IUPAC name is 1,1,2,2-tetradeuterio-2-(1H-imidazol-5-yl)ethanamine. Common synonyms include 2-(1H-Imidazol-5-yl)(~2~H_4_)ethan-1-amine and histamine-alpha,alpha,beta,beta-d4.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Histamine-d4 Dihydrochloride is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Histamine

View every impurity, metabolite and intermediate we list for Histamine.

Histamine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Histamine-d4 Dihydrochloride
Catalogue No.	VQ-037585
CAS Number	344299-48-5
IUPAC name	1,1,2,2-tetradeuterio-2-(1H-imidazol-5-yl)ethanamine
Molecular formula	C₅H₉N₃
Molecular weight	115.17 g/mol
Exact mass	115.1048
Grade	Reference Standard
HSN code	38229090
InChIKey	NTYJJOPFIAHURM-LNLMKGTHSA-N
SMILES	[2H]C([2H])(C1=CN=CN1)C([2H])([2H])N
PubChem CID	45039382

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.7
H-bond donors / acceptors	2 / 2
TPSA	54.7 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation

Precautionary statements: P233, P260, P261, P264, P264 + P265, P271, P272, P280, P284, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P333 + P317, P337 + P317, P342 + P316, P362 + P364, P403, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Histamine-d4 Dihydrochloride?

The CAS Registry Number of Histamine-d4 Dihydrochloride is 344299-48-5. It is also known as Histamine-alpha,alpha,beta,beta-D4 Dihydrochloride, 2-(1H-Imidazol-5-yl)(~2~H_4_)ethan-1-amine, histamine-alpha,alpha,beta,beta-d4.

What is the molecular formula and molecular weight of Histamine-d4 Dihydrochloride?

Histamine-d4 Dihydrochloride has the molecular formula C5H9N3 and a molecular weight of 115.17 g/mol. Its IUPAC name is 1,1,2,2-tetradeuterio-2-(1H-imidazol-5-yl)ethanamine.

What is Histamine-d4 Dihydrochloride used for?

Histamine-d4 Dihydrochloride is supplied as a characterised reference material related to Histamine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Histamine-d4 Dihydrochloride can I order?

We supply Histamine-d4 Dihydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Histamine-d4 Dihydrochloride?

Yes. Every lot of Histamine-d4 Dihydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Histamine-d4 Dihydrochloride be shipped internationally?

Yes. Histamine-d4 Dihydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.