Pemetrexed disodium heptahydrate

About Pemetrexed disodium heptahydrate

Pemetrexed disodium heptahydrate is a high-purity reference standard of Pemetrexed carrying the CAS registry number 357166-29-1. The compound has the formula C20H33N5Na2O13, corresponding to a molecular weight of 597.5 g/mol. Common synonyms include Pemetrexed sodium hydrate and Pemetrexed Disodium Salt Heptahydrate.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Pemetrexed, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Pemetrexed

View every impurity, metabolite and intermediate we list for Pemetrexed.

Pemetrexed impurities

Specifications & identifiers

Chemical identifiers
Product name	Pemetrexed disodium heptahydrate
Catalogue No.	VQ-033088
CAS Number	357166-29-1
IUPAC name	disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;heptahydrate
Molecular formula	C₂₀H₃₃N₅Na₂O₁₃
Molecular weight	597.5 g/mol
Exact mass	597.187
Grade	Reference Standard
HSN code	38229090
InChIKey	QJVSMHJWAOSBMD-MYXYZBIASA-L
SMILES	C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.O.O.[Na+].[Na+]
PubChem CID	135564751

Physical properties
Physical form	Solid
H-bond donors / acceptors	11 / 14
TPSA	200 Å²
Synonyms	Pemetrexed sodium hydrate, Pemetrexed Disodium Salt Heptahydrate, Pemetrexed sodium hydrate (JAN), Pemetrexed Disodium 7 Hydrate, Pemetrexed (sodium salt hydrate), (S)-pemetrexed disodium heptahydrate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pemetrexed disodium heptahydrate?

The CAS Registry Number of Pemetrexed disodium heptahydrate is 357166-29-1. It is also known as Pemetrexed sodium hydrate, Pemetrexed Disodium Salt Heptahydrate, Pemetrexed sodium hydrate (JAN).

What is the molecular formula and molecular weight of Pemetrexed disodium heptahydrate?

Pemetrexed disodium heptahydrate has the molecular formula C20H33N5Na2O13 and a molecular weight of 597.5 g/mol.

What is Pemetrexed disodium heptahydrate used for?

Pemetrexed disodium heptahydrate is supplied as a characterised reference material related to Pemetrexed. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pemetrexed disodium heptahydrate can I order?

We supply Pemetrexed disodium heptahydrate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pemetrexed disodium heptahydrate?

Yes. Every lot of Pemetrexed disodium heptahydrate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pemetrexed disodium heptahydrate be shipped internationally?

Yes. Pemetrexed disodium heptahydrate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.