5-Bromo-2,4-dichloropyrimidine

About 5-Bromo-2,4-dichloropyrimidine

5-Bromo-2,4-dichloropyrimidine is an impurity of Ribociclib carrying the CAS registry number 36082-50-5. The compound has the formula C4HBrCl2N2, corresponding to a molecular weight of 227.87 g/mol. It is also known as 2,4-dichloro-5-bromopyrimidine or 2,6-dichloro-5-bromopyrimidine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Ribociclib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Ribociclib

View every impurity, metabolite and intermediate we list for Ribociclib.

Ribociclib impurities

Specifications & identifiers

Chemical identifiers
Product name	5-Bromo-2,4-dichloropyrimidine
Catalogue No.	VQ-033029
CAS Number	36082-50-5
IUPAC name	5-bromo-2,4-dichloropyrimidine
Molecular formula	C₄HBrCl₂N₂
Molecular weight	227.87 g/mol
Exact mass	225.87
Grade	Reference Standard
HSN code	38229090
InChIKey	SIKXIUWKPGWBBF-UHFFFAOYSA-N
SMILES	C1=C(C(=NC(=N1)Cl)Cl)Br
PubChem CID	289973

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	0 / 2
TPSA	25.8 Å²
Synonyms	2,4-dichloro-5-bromopyrimidine, 2,6-dichloro-5-bromopyrimidine, 2,4-Dichloro-5-bormopyrimidine, Discontinued, see D433775, 5-bromo-2,4-dichlorpyrimidine

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301+H311+H331Toxic if swallowed, in contact with skin or if inhaled
H301Toxic if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H331Toxic if inhaled

Precautionary statements: P260, P261, P262, P264, P270, P271, P272, P280, P301 + P316, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P321, P330, P333 + P317, P361 + P364, P362 + P364, P363, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-Bromo-2,4-dichloropyrimidine?

The CAS Registry Number of 5-Bromo-2,4-dichloropyrimidine is 36082-50-5. It is also known as 2,4-dichloro-5-bromopyrimidine, 2,6-dichloro-5-bromopyrimidine, 2,4-Dichloro-5-bormopyrimidine.

What is the molecular formula and molecular weight of 5-Bromo-2,4-dichloropyrimidine?

5-Bromo-2,4-dichloropyrimidine has the molecular formula C4HBrCl2N2 and a molecular weight of 227.87 g/mol. Its IUPAC name is 5-bromo-2,4-dichloropyrimidine.

What is 5-Bromo-2,4-dichloropyrimidine used for?

5-Bromo-2,4-dichloropyrimidine is supplied as a characterised reference material related to Ribociclib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-Bromo-2,4-dichloropyrimidine can I order?

We supply 5-Bromo-2,4-dichloropyrimidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-Bromo-2,4-dichloropyrimidine?

Yes. Every lot of 5-Bromo-2,4-dichloropyrimidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-Bromo-2,4-dichloropyrimidine be shipped internationally?

Yes. 5-Bromo-2,4-dichloropyrimidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.