2-Nitrosoisoindoline-1,3-dione

About 2-Nitrosoisoindoline-1,3-dione

2-Nitrosoisoindoline-1,3-dione is a nitrosamine impurity of Rivaroxaban carrying the CAS registry number 364745-13-1. With the molecular formula C8H4N2O3, it has a molar mass of 176.13 g/mol. The IUPAC name is 2-nitrosoisoindole-1,3-dione. Alternative names: 2-nitroso-1H-isoindole-1,3(2H)-dione and N-Nitrosophthalimide.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Rivaroxaban, method validation (AMV) and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Rivaroxaban

View every impurity, metabolite and intermediate we list for Rivaroxaban.

Rivaroxaban impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Nitrosoisoindoline-1,3-dione
Catalogue No.	VQ-041950
CAS Number	364745-13-1
IUPAC name	2-nitrosoisoindole-1,3-dione
Molecular formula	C₈H₄N₂O₃
Molecular weight	176.13 g/mol
Exact mass	176.0222
Grade	Reference Standard
HSN code	38229090
InChIKey	QYBUCATUCRELKA-UHFFFAOYSA-N
SMILES	C1=CC=C2C(=C1)C(=O)N(C2=O)N=O
PubChem CID	458417

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	0 / 4
TPSA	66.8 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Nitrosoisoindoline-1,3-dione?

The CAS Registry Number of 2-Nitrosoisoindoline-1,3-dione is 364745-13-1. It is also known as 2-nitroso-1H-isoindole-1,3(2H)-dione, N-Nitrosophthalimide, 2-nitrosobenzo[c]azolidine-1,3-dione.

What is the molecular formula and molecular weight of 2-Nitrosoisoindoline-1,3-dione?

2-Nitrosoisoindoline-1,3-dione has the molecular formula C8H4N2O3 and a molecular weight of 176.13 g/mol. Its IUPAC name is 2-nitrosoisoindole-1,3-dione.

What is 2-Nitrosoisoindoline-1,3-dione used for?

2-Nitrosoisoindoline-1,3-dione is supplied as a characterised reference material related to Rivaroxaban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Nitrosoisoindoline-1,3-dione can I order?

We supply 2-Nitrosoisoindoline-1,3-dione in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Nitrosoisoindoline-1,3-dione?

Yes. Every lot of 2-Nitrosoisoindoline-1,3-dione is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Nitrosoisoindoline-1,3-dione be shipped internationally?

Yes. We export 2-Nitrosoisoindoline-1,3-dione worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.