N-Desmethyl bosutinib

Name: N-Desmethyl bosutinib
Brand: Vaqora Chemicals
SKU: VQ-020976

About N-Desmethyl bosutinib

Listed under CAS 380843-81-2, N-Desmethyl bosutinib is a metabolite or degradation product of Bosutinib available from Vaqora Chemicals. Formula C25H27Cl2N5O3, molecular weight 516.4 g/mol. Systematically, it is named 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-(3-piperazin-1-ylpropoxy)quinoline-3-carbonitrile. It is also known as Bosutinib metabolite M5 or N-Desmethyl Bousutinib.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Bosutinib, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Bosutinib

View every impurity, metabolite and intermediate we list for Bosutinib.

Bosutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl bosutinib
Catalogue No.	VQ-020976
CAS Number	380843-81-2
IUPAC name	4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-(3-piperazin-1-ylpropoxy)quinoline-3-carbonitrile
Molecular formula	C₂₅H₂₇Cl₂N₅O₃
Molecular weight	516.4 g/mol
Exact mass	515.1491
Grade	Reference Standard
HSN code	38229090
InChIKey	WJNXCARNBUNEMQ-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)C(=C(C=N2)C#N)NC3=CC(=C(C=C3Cl)Cl)OC)OCCCN4CCNCC4
PubChem CID	5328944

Physical properties
Physical form	Solid
LogP (XLogP3)	4.9
H-bond donors / acceptors	2 / 8
TPSA	91.7 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl bosutinib?

The CAS Registry Number of N-Desmethyl bosutinib is 380843-81-2. It is also known as Bosutinib metabolite M5, N-Desmethyl Bousutinib, 4-Phenylamino-3-quinolinecarbonitrile deriv. 31e.

What is the molecular formula and molecular weight of N-Desmethyl bosutinib?

N-Desmethyl bosutinib has the molecular formula C25H27Cl2N5O3 and a molecular weight of 516.4 g/mol. Its IUPAC name is 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-(3-piperazin-1-ylpropoxy)quinoline-3-carbonitrile.

What is N-Desmethyl bosutinib used for?

N-Desmethyl bosutinib is supplied as a characterised reference material related to Bosutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl bosutinib can I order?

We supply N-Desmethyl bosutinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl bosutinib?

Yes. Every lot of N-Desmethyl bosutinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl bosutinib be shipped internationally?

Yes. We export N-Desmethyl bosutinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.