Ethyl chlorodifluoroacetate

About Ethyl chlorodifluoroacetate

Ethyl chlorodifluoroacetate is a process intermediate or related compound of Deracoxib carrying the CAS registry number 383-62-0. The compound has the formula C4H5ClF2O2, corresponding to a molecular weight of 158.53 g/mol. Systematically, it is named ethyl 2-chloro-2,2-difluoroacetate. Common synonyms include Ethyl chlorodifluoroethanoate and Acetic acid, chlorodifluoro-, ethyl ester.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Deracoxib, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Ethyl chlorodifluoroacetate in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Deracoxib

View every impurity, metabolite and intermediate we list for Deracoxib.

Deracoxib impurities

Specifications & identifiers

Chemical identifiers
Product name	Ethyl chlorodifluoroacetate
Catalogue No.	VQ-051622
CAS Number	383-62-0
IUPAC name	ethyl 2-chloro-2,2-difluoroacetate
Molecular formula	C₄H₅ClF₂O₂
Molecular weight	158.53 g/mol
Exact mass	157.9946
InChIKey	GVCAWQUJCHZRCB-UHFFFAOYSA-N
SMILES	CCOC(=O)C(F)(F)Cl
PubChem CID	67843

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	0 / 4
TPSA	26.3 Å²
Synonyms	Ethyl chlorodifluoroethanoate, Acetic acid, chlorodifluoro-, ethyl ester, Acetic acid, 2-chloro-2,2-difluoro-, ethyl ester, Chlorodifluoroacetic Acid Ethyl Ester, ethyl difluorochloroacetate, ethyl 2-chloro-2,2-difluoro-acetate, ethyl chlordifluoroacetate, Chloro-difluoro-acetic acid ethyl ester

Safety & hazard information (GHS)

Flammable

Corrosive

Signal word: Danger

Hazard statements

H225Highly flammable liquid and vapor
H314Causes severe skin burns and eye damage
H318Causes serious eye damage

Precautionary statements: P210, P233, P240, P241, P242, P243, P260, P264, P264 + P265, P280, P301 + P330 + P331, P302 + P361 + P354, P303 + P361 + P353, P304 + P340, P305 + P354 + P338, P316, P317, P321, P363, P370 + P378, P403 + P235, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ethyl chlorodifluoroacetate?

The CAS Registry Number of Ethyl chlorodifluoroacetate is 383-62-0. It is also known as Ethyl chlorodifluoroethanoate, Acetic acid, chlorodifluoro-, ethyl ester, Acetic acid, 2-chloro-2,2-difluoro-, ethyl ester.

What is the molecular formula and molecular weight of Ethyl chlorodifluoroacetate?

Ethyl chlorodifluoroacetate has the molecular formula C4H5ClF2O2 and a molecular weight of 158.53 g/mol. Its IUPAC name is ethyl 2-chloro-2,2-difluoroacetate.

What is Ethyl chlorodifluoroacetate used for?

Ethyl chlorodifluoroacetate is supplied as a characterised reference material related to Deracoxib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ethyl chlorodifluoroacetate can I order?

We supply Ethyl chlorodifluoroacetate, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ethyl chlorodifluoroacetate?

Yes. Every lot of Ethyl chlorodifluoroacetate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ethyl chlorodifluoroacetate be shipped internationally?

Yes. Ethyl chlorodifluoroacetate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.