H-Thr(tBu)-OH

Name: H-Thr(tBu)-OH
Brand: Vaqora Chemicals
SKU: VQ-052318

About H-Thr(tBu)-OH

H-Thr(tBu)-OH (CAS 4378-13-6) is a process intermediate or related compound of Threonine offered by Vaqora Chemicals. Formula C8H17NO3, molecular weight 175.23 g/mol. Systematically, it is named (2S,3R)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoic acid. Common synonyms include O-tert-Butyl-L-Threonine and (2S,3R)-2-Amino-3-(tert-butoxy)butanoic acid.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

It is a process intermediate or related compound in the synthesis of Threonine, useful for route development, impurity fate-and-purge studies and analytical method development. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Threonine

View every impurity, metabolite and intermediate we list for Threonine.

Threonine impurities

Specifications & identifiers

Chemical identifiers
Product name	H-Thr(tBu)-OH
Catalogue No.	VQ-052318
CAS Number	4378-13-6
IUPAC name	(2S,3R)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoic acid
Molecular formula	C₈H₁₇NO₃
Molecular weight	175.23 g/mol
Exact mass	175.1208
InChIKey	NMJINEMBBQVPGY-RITPCOANSA-N
SMILES	C[C@H]([C@@H](C(=O)O)N)OC(C)(C)C
PubChem CID	6951357

Physical properties
Physical form	Solid
LogP (XLogP3)	-2.1
H-bond donors / acceptors	2 / 4
TPSA	72.6 Å²
Synonyms	O-tert-Butyl-L-Threonine, (2S,3R)-2-Amino-3-(tert-butoxy)butanoic acid, O-(1,1-Dimethylethyl)-L-threonine, O-(tert-Butyl)-L-threonine, L-Threonine, O-(1,1-dimethylethyl)-, O-t-Butyl-L-threonine, O-tert-Butyl-L-allo-threonine, (2S,3R)-2-Amino-3-(tert-butoxy)butanoicacid, O-tert.Butyl-L-threonine, (2S,3R)-2-azaniumyl-3-[(2-methylpropan-2-yl)oxy]butanoate, O-tert.-Butylthreonin, Threonine tert-butyl ether

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of H-Thr(tBu)-OH?

The CAS Registry Number of H-Thr(tBu)-OH is 4378-13-6. It is also known as O-tert-Butyl-L-Threonine, (2S,3R)-2-Amino-3-(tert-butoxy)butanoic acid, O-(1,1-Dimethylethyl)-L-threonine.

What is the molecular formula and molecular weight of H-Thr(tBu)-OH?

H-Thr(tBu)-OH has the molecular formula C8H17NO3 and a molecular weight of 175.23 g/mol. Its IUPAC name is (2S,3R)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoic acid.

What is H-Thr(tBu)-OH used for?

H-Thr(tBu)-OH is supplied as a characterised reference material related to Threonine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of H-Thr(tBu)-OH can I order?

We supply H-Thr(tBu)-OH, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with H-Thr(tBu)-OH?

Yes. Every lot of H-Thr(tBu)-OH is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can H-Thr(tBu)-OH be shipped internationally?

Yes. H-Thr(tBu)-OH is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.